Risk factors, Diagnostic Parameters, and Cellular Identification of Ovarian Malignancy: A Brief Review

Women are most likely to develop ovarian carcinoma, the leading source of transience and morbidity for cancers that affect women. As the seventh greatest deadly malignancy among women, it is composed of heterogeneous groups of neoplasms. Studies have identified numerous endogenous and exogenous factors associated with ovarian cancer development. The International Federation released a report of Obstetrics and Gynaecology (FIGO) on this development has led to a revision of the staging system to provide prognostic information and recommendations regarding the treatment of ovarian cancer. Various cancer drugs have been developed over the past several years that are less toxic and more effective, so there is an increasing need for exact and consistent cancer diagnostics and prognoses. In managing ovarian cancer, biomarkers have helped separate benign from malignant masses in the pelvis and monitor response to treatment. Over the past four decades, CA125 has been the primary marker for ovarian cancer. This study is intended to present an updated global view of epithelial ovarian carcinoma, the most common form

A Review on Herbal Formulation in the Management of Vitiligo

Dysfunction or death of pigment-producing cells causes vitiligo. As a result, white patches or macules can appear anywhere on the body including the mouth, eyes, hair, and other areas. Vitiligo is more noticeable in darken skin people. It is not contagious or life-threatening but may lead to mental stress or get down to one’s self-confidence. It occurs in both males and females. There is a wide variety of medical treatments available for those suffering from vitiligo. The treatment range from steroid creams to phototherapy, to surgery. Plant-based therapeutic preparation is recurrent to complement dermatological therapy. There is the use of traditional herbal drugs in vitiligo treatment. Some herbs are used topically on one’s skin or orally consumed which helps in minimizing or decreasing the white patches or macules. Herbal drug constituents like capsaicin, piperine, curcumin, khellin, and green tea polyphenols having antioxidant, anti-inflammatory, and anti-necrobiosis properties are found to have very effective treatment options for vitiligo.

Effect of Mucor mycosis associated with covid-19 affecting lives

 Mycosis is caused by a fungus belonging to the Mucorales order and the Zygomycetes class is known as Mucor mycosis. Mucor mycosis is generally known as black fungus disease. This infection primarily goals diabetic and immunocompromised patients. As COVID-19 infection drops the immunity of patients, mucormycotic cases are also growing due to inhalation of molds containing industrial oxygen. The key objective of the present article is to deliver a wide-ranging review on Mucor mycosis, its epidemiology, diagnosis, treatment, pathophysiology, and its association with COVID-19. Mucor mycosis is a rare invasive fungal infection that has a developed mortality rate if not diagnosed well. There are six forms of Mucor mycosis based on anatomical localization such as pulmonary, cutaneous, rhino cerebral, gastrointestinal, miscellaneous, and disseminated. Patients receiving treatment for iron overload Assume a higher risk of getting black fungus. The finding and treatment of Mucor mycosis are characteristically tough based on sputum culture, imaging analysis, and Broncho alveolar lavage culture. Treatment with Amphotericin B and suitable surgery can rise the survival rate up to 1.5 folds. COVID-19 infected patients with black fungus are getting first-line treatment with antifungal drugs to moderate the infections. Abundant research is required for the encounter of new drug therapy in the coming future.

Formulation and In vitro Evaluation of Aceclofenac sustained release tablet

In the present investigation, an attempt was made to improve the dissolution rate of Aceclofenac by preparing and evaluating a sustained drug delivery system of aceclofenac tablets with different grade polymere HPMC K4M, HPMC K100 M and compared with pure drug. The prepared dispersion were evaluated for their physiochemical and dissolution characteristics.

Molecular Pathogenesis and Curbing Aspects of Lung Melanoma: A Review

 Nowadays among the most decisive diseases cancer is the most fatal disorder which accounts for about ~ 19.3 million deaths in a worldwide scenario. The forecasting etiological parameter comprises smoking, radiation, parental history, environmental factors, and stress. Radiation therapy, chemotherapy, and removal of solid tumors by the surgical method are known as former treatments. But in chemotherapy, the main quantifiable drawbacks occur due to limitation in the entrapment of drug from the site of application to the desired tumor tissue. To challenge the former diagnosis, researchers have invented a new and remarkable boon called "targeted delivery" which plays an eye-catching and significant therapeutic efficacy of the chemotherapeutics agent via liposomal drug delivery system with a notable curbing approach. The reward of liposome as a theranostic carrier over conventional dosage forms represented by their bioavailability, enhanced solubility, low systemic toxicity, and their ability to encapsulate both the hydrophilic and hydrophobic drugs. The existing approaches used for liposomal drug delivery are active targeting and passive targeting. In this context liposomal system offers a confined platform for targeted delivery to the lungs loaded with anti-cancer active pharmaceutical ingredients by encapsulation within the liposomal core which serves as the most promising diagnostic head to break the overwhelming growth of lung malignancy.

FORMULATION AND EVALUATION OF HERBAL GEL OF GUAVA LEAVES EXTRACT FOR THE TREATMENT OF MOUTH ULCER

Fabrication of silver nanoparticles Using Microbes: A Review