About Me |
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Working here at centurion since 2018 in school of pharmacy & life sciences at Rayagada campus. Prior to this worked in various clinical trial projects at Apollo Hospitals Educational and Research Foundation, hyderabad, L V Prasad eye research institute, hyderabad for 3 years and also worked in pharmacovigilance as a drug safety associate at Accenture chennai for 1.6 years. I had a teaching experience of 1.5 year before this in Syncorp clinicare, hyderabad. |
- Diabetes
- (Pharmacology)
- (Human Anatomy & Physiology)
- (Pathophysiology)
- (Pharmacy Practice)
- (Pharmacotherapeutics)
- (pharmacology)
- (Pharmacovigilance)
- (clinical trials)
- (clinical trials) (Pharmacovigilance)
Research Fields
Synergistic activity of Glimepiride (A synthetic drug) and Naringin (A Flavonoid) in streptozotocin induced diabetic rats
Recent Publications (International Journals)
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Academic Honors & Awards
An Overview on Ethnopharmacology of Different Medicinal Plants of Odisha State of India in the Management of Diabetes Mellitus
Diabetes mellitus, commonly known as diabetes, is a group of metabolic disorder associated with elevated blood glucose level. World
health organization recommended the traditional and herbal remedies for the diabetic management. The application of herbal remedies is
extremely increased worldwide in the last three decades. Most of the synthetic drugs were discovered from the plant source out of
different regions of the world to meet the demand. Several medicinal plants like Gymnema sylvestre, Pterocarpus marsupium, Catharanthus
roseus, Trigonella foenum, Annona squamosa, Aegle marmelos, Withania somnifera, Boerhavia diffusa, Boerhavia erecta, Momordica
charantia, Cocos nucifera, Ricinus communis, Azadira chtaindica and Aloe vera have been reported to have varying level of hypoglycemic
property. One of the factors involved in the evolution of diabetic convolutions is the impairment due to free radicals and hence a compound
with antioxidant and antidiabetic potential would be more effective. The present review article was designed to provide an absolute data
on these medicinal plant based remedies by using the traditional healers of Odisha state, India.
PREVENTIVE ROLE OF NARINGIN IN DIABETES MELLITUS AND ITS MECHANISM OF ACTION : A REVIEW
Diabetes is a chronic metabolic ailment that causes abnormal metabolism of carbohydrates and shows high blood glucose
level which is due to either deficiency in insulin secretion or there is an impairment in insulin action. The traditional and plant
based remedies for the management of diabetes has been approved by the world health organization. Over the last three
decades the use of herbal medicines is increased enormously worldwide. From the plant source most of the synthetic drugs
were discovered from different regions of the world to meet the need. The objective of this review was to provide information
about the most useful anti-diabetic compounds from plants available through numerous literature sources from various
databases. Many researches confirmed the benefits of phytoconstituents with anti-diabetic effects in the management of
diabetes mellitus. Thus, drugs from plants may control all pathological aspects of diabetes, either by increasing insulin
production by the pancreas, helping to lower the body’s insulin requirements, or reducing gluconeogenesis in the liver. One
of the factor involved in the development of diabetic complications is the damage occurred by free radicals and hence an antidiabetic compound with anti-oxidant properties would be more beneficial. The present review article is designed to potentiate
the activity of a plant based product naringin for its anti-diabetic potential and for other metabolic diseases also. This
compound is broadly available in Orange peels and hence its application in treatment of diabetes especially type two
diabetes mellitus is found to be cost effective.
Synergistic Effect of Naringin and Glimepiride in Streptozotocin-induced Diabetic Rats
Objective: Evaluation of the synergistic effect of Naringin and Glimepiride in streptozotocin (STZ)-induced diabetic rats.
Methods: Wistar rats were chosen and divided into five groups (n=6). STZ was used for the induction of diabetes. The combination of naringin and glimepiride was administered to diabetic rats. The changes in fasting blood sugar, body weight, Hb, HbA1c, and creatinine were evaluated, and urine was collected and the volume was observed. The lipid profiles like TC, HDL, LDL, and TG were measured. The biochemical parameters SGOT, SGPT, and ALP were analysed. Besides, endogenous antioxidant parameters like SOD, GSH, and catalase were also assessed. Lastly, the histopathological study of the beta cells in islets of the pancreas, glomerulus, and tubules of kidney and liver cells was conducted in all groups.
Results: The result shows significant reduction (p<0.001) of blood sugar in the naringin and glimepiride-treated group when compared with the control group (diabetes). Additionally, the combination of Naringin (100 mg/kg) and Glimepiride (0.1 mg/kg) significantly restores the creatinine levels and urine volumes, SGOT, SGPT, and ALP when compared to a single dose of administration. Further, the abnormal lipid profile levels (TC, LDL, TG, and HDL), and endogenous antioxidant enzymes (SOD, GSH, catalase) in diabetic control rats were restored to normal levels in a significant manner. The histopathological result reveals significant alterations, including hypertrophy of islets and mild degeneration, renal necrosis, and inflammation of hepatocytes.
Conclusion: A synergistic effect of Naringin and glimepiride was observed during the estimation of various biochemical parameters like body weight, fasting blood sugar, creatinine, urine level, TG, total cholesterol, SGOT, SGPT, ALP, Insulin, HbA1c, antioxidant parameters like SOD, GSH, and catalase in STZ-induced diabetic rats. Further, the combination of therapy improves the protective effect of the pancreas, kidney, and liver, suggesting a potential antidiabetic effect.
Osseous implications of proton pump inhibitor therapy: An umbrella review
Background: Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide for acid-related disorders. While their short-term efficacy and safety are well-established, concerns regarding their long-term effects on bone health have emerged. This umbrella review aimed to synthesize the available findings on the associations between PPI use and bone metabolism outcomes. Methods: An electronic search was conducted using PubMed, Web of Science, Embase, and the Cochrane Database up to September 16, 2023. Systematic reviews and meta-analyses of randomized controlled trials (RCTs) and observational studies that evaluated the relationship between PPIs and bone metabolism outcomes were included. Data extraction, quality appraisal, and synthesis were performed in line with the Joanna Briggs Institute and PRISMA guidelines. The strength of the evidence was graded using the GRADE criteria. Statistical analysis was performed in R version 4.3. Results: Out of 299 records, 27 studies met the inclusion criteria. The evidence indicated a statistically significant increased risk of fractures, notably hip, spine, and wrist fractures, in PPI users. PPI use was associated with changes in Bone Mineral Density (BMD) across various bones, though the clinical relevance of these changes remains uncertain. Furthermore, PPI-induced hypomagnesemia, which can influence bone health, was identified. A notable finding was the increased risk of dental implant failures in PPI users. However, the certainty of most of the evidence ranged from very low to low based on GRADE criteria. Conclusion: The long-term use of PPIs may be associated with adverse bone health outcomes, including increased fracture risk, alterations in BMD, hypomagnesemia, and dental implant failure. While these findings highlight
A Comprehensive Review on Promising Phytopharmacological Applications of Chamomile Flower
Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most favoured single ingredient herbs.
Chamomile tea is prepared by brewing the dried flower heads which has been used as traditional remedy. It is a crop introduced into India,
mainly grown in Assam, Uttar Pradesh, Jammu & Kashmir states of India. The valuable unknown properties of this multipurpose herb
should be explored to determine the therapeutic properties of its different parts, extracts, oils, etc. The flowers constitute many phenolic
compounds like flavonoids, apigenin, patuletin, glucosides, luteolin and quercetin as main components. This herb is used as an antioxidant,
antidepressant, antidiarrheal, antimicrobial, anti-inflammatory, antidiabetic, anticarcinogenic and hepatoprotective agents. In addition to
that, it is also useful in treatment of gastrointestinal disorders, premenstrual syndrome, knee osteoarthritis andulcerative colitis. Matricaria
Recutita chamomilla L. is used for both therapeutically and non-therapeutically around the globe that precipitate its remarkable worth.
Chamomile contents of essential oils are widely used in aromatherapy and cosmetics. Most popular chamomile preparation is herbal tea
which has been developed and consumed by more than one million cups per day across the globe. This review article briefs about the
therapeutic efficiency along with phytology and cultivation techniques.
Phytochemistry and pharmacology of Curculigo orchioides Gaertn: A review
Curculigo orchioides Gaertn. is a rare rasayana herb (family Amaryllidaceae) popularly known as “Kali Musli”. Traditionally used in Ayurvedic medicine as an aphrodisiac and adaptogen, the plant is native to India. There is evidence that the plant contains mucilage, phenolic glycosides, saponins, and aliphatic compounds. This folk medicine can treat a wide range of ailments, including impotency, aphrodisiacs, tonics, jaundice, and skin conditions. There are also many scientists who have investigated its antioxidant, anticancer, and hepatoprotective properties. Curculigo was isolated for its chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides, and polysaccharides. As an herbal medicine, Curculigo’s quality can be controlled through new analyzing methods. Furthermore, Curculigo has been investigated for its pharmacological activity against diabetes, bacteria, inflammation, osteoporosis, oxidative stress, cancer, and neurodegeneration. Scientific methods were gradually developed for the application of herbal medicine. A more comprehensive pharmacological study of the genus Curculigo is needed to determine its medicinal value. An updated and comprehensive review of the medicinal plant C. orchioides Gaertn is presented here describing traditional uses, phytochemistry, pharmacology, and toxicology, and understanding its future research and development prospects.
Promising Flavonoids Against Neuropathic Pain: Their Mechanism And Therapeutic Opportunities
Flavonoids and their Role in the Remedy of Diabetes Mellitus: A Review
The impact of diabetes mellitus on the health care system is significant due to its global prevalence affecting millions of individuals. This condition is commonly related with factors such as obesity, urbanization, and genetic alterations. Those with diabetes mellitus have elevated blood glucose levels because an inability to produce, secrete or bind to insulin causes a lowering of insulin levels. Flavonoids are phenolic compounds found in fruits, vegetables and fungi. Carbon atoms are comprised of 15 chains of three carbon atoms in a skeleton. The anthocyanidin family includes flavonoids, flavones, flavanones, isoflavones, flavanols and flavonoids. In addition to their antidiabetic properties, flavonoids also have antioxidant properties. Molecular mechanisms underlying the antidiabetic properties of dietary flavonoids are summarized in this review. Other natural compounds with antidiabetic properties include cosmosiin, didymin, diosmin, naringin, isosiennsetin, nobiletin, poncirin, quercetin, rhoifolin, sinensetin, naringenin, sudachitin, rutin, hesperidin and tangeretin, which also improve lipid and phospholipid metabolism. The progression of diabetes is influenced by diabetes biomarkers. Citrus flavonoids are therefore promising candidates for antidiabetic action, even though further research is necessary to prove their effectiveness.