“Preparation, characterization and in-vitro evaluation of sustain release protein loaded nanoparticle based on biodegradable polymers

Controlled drug delivery technology of proteins/peptides from biodegradable nanoparticles has emerged as one of the eminent areas to overcome formulation associated problems of the macromolecules. The purpose of the present investigation was to develop protein-loaded nanoparticles using biodegradable polymer poly l-lactide-co-glycolidic acid (PLGA) with bovine serum albumin (BSA) as a model protein. Despite many studies available with PLGA-based protein-loaded nanoparticles, production know-how, process parameters, protein loading, duration of protein release, narrowing polydispersity of particles have not been investigated enough to scale up manufacturing of protein-loaded nanoparticles in formulations. Different process parameters such as protein/polymer ratio, homogenizing speed during emulsifications, particle surface morphology and surface charges, particle size analysis and in-vitro

Self-Emulsifying Drug Delivery Systems: An Attempt To Improve Oral Absorption Of Poorly Soluble Drugs

Self emulsifying drug delivery systems (SEDDS) have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. The oral route of drug delivery is typically considered the preferred and most patient convenient means of drug administration. However, more than 40% of new chemical entities exhibit poor aqueous solubility. SEDDS have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SEDDS are isotropic mixtures of oils and surfactants, sometimes containing cosolvents, and can be used for the design of formulations in order to improve the oral absorption of highly lipophilic compounds. In SEDDS mixture of hydrophobic drug, surfactant with or without cosurfactant is mixed and then formulated either in soft gelatin capsule or in hard gelatin capsule. After administering the drug by this system, emulsion is formed in the GIT with aqueous GI fluied due to peristaltic movement of GIT

Preparation and invivo evaluation of sustained release matrix tablets of phynytoin sodium using natural polymer

The aim of the present study was to develop sustained release matrix tablets of phenytoin sodium an antiepileptic drug. Advantages of sustained-release tablets are that they can often be taken less frequently than instant release formulations of the same drug, and that they keep steady levels of the drug in the blood stream. The tablets were fabricated by the wet granulation method using water as granulating agent along with matrix materials like guar gum, sodium alginate, tragacanth and xanthan gum with varying percentage. The granules were evaluated for angle of repose, bulk density, compressibility index, total porosity, and drug content. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. The swelling behavior of matrix was also investigated. The granules showed satisfactory flow properties, compressibility, and drug content. The IR spectral analysis studies confirmed no interaction between phenytoin with used natural gums. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters.

Optimization of fast disintegrating tablets for diclofenac sodium using isabgol mucilage as superdisintegrant

Fast disintegrating tablets used for administration in the oral cavity were prepared either by direct compression or by wet granulation method. The The disintegration time of conventional tablets was reduced from 10 minutes to a minimum of 23 seconds by introducing 2-5% of dried isabgol extract. By optimizing moisture content of the granules, tablets meeting tensile strength greater than 0.6 MPa and disintegration time shorter than 100 s were obtained by the wet compression method. The tensile strength of the tablet increased remarkably in tablets prepared by wet granulation process, while the porosity of the tablet seemed almost unchanged. Superdisintegrant features of isbagol was further optimized by water absorption and in vitro dispersion time. Wetting time and disintegration time matched with the requirements of EP, Dissolution profiles suggested that the superdisintegrants action of the dried isabgol mucilage enhanced the release of the drug from tablets with respect to conventional marketed. Moreover, Directly compressed tablets released drug rapidly as compared to wet granulation process.

“Comparative studying on various tableting properties of phenytoin sodium mouth dissolving dosage form using spherical crystals

The aim of the present study was to develop sustained release matrix tablets of phenytoin sodium an antiepileptic drug. Advantages of sustained-release tablets are that they can often be taken less frequently than instant release formulations of the same drug, and that they keep steady levels of the drug in the blood stream. The tablets were fabricated by the wet granulation method using water as granulating agent along with matrix materials like guar gum, sodium alginate, tragacanth and xanthan gum with varying percentage. The granules were evaluated for angle of repose, bulk density, compressibility index, total porosity, and drug content. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. The swelling behavior of matrix was also investigated. The granules showed satisfactory flow properties, compressibility, and drug content. The IR spectral analysis studies confirmed no interaction between phenytoin with used natural gums. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters

“Nanosuspension: An Attempt To Enhance Bioavailability of Poorly Soluble Drugs”

Most of the new chemical entities coming out from Highthroughput screening in drug discovery process are failing due to their poor solubility in the water. Poorly water-soluble drugs show many problems in formulating them in conventional dosage forms. One of the critical problems associated with poorly soluble drugs is too low bioavailability. The problem is even more complex for drugs belonging to BCS CLASS II category, as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2. There are number of formulation approaches to resolve the problems of low solubility and low bioavailability. These techniques for solubility enhancement have some limitations and hence have limited utility in solubility enhancement. Nanotechnology can be used to resolve the problems associated with these conventional approaches for solubility and bioavailability enhancement. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10-9 meters. The present article describes the details about nanosuspensions. Nanosuspensions consist of the pure poorly water-soluble drug without any matrix material suspended in dispersion.

"Nanovehicles: An efficient carrier for active molecucles for entry in to the cell

Nanovehicle as a carriers offer exclusive possibilities to overwhelmed cellular obstruction in order to improve the delivery of active substances, including the promising therapeutic biomacromolecules (i.e., nucleic acids, proteins). There are number of mechanisms lead to nanocarrier cellular internalization that is desperately affected by nanoparticles’ physicochemical properties. The pharmacological actions of nanocarriers may be depends on the different paths cellular uptake and intracellular trafficking. In this article we are trying to foccus on several opportunities, starting with the phagocytosis pathway, which has followed in the treatment of certain cancer and various infectious diseases. On the other side, the non-phagocytic pathways accomplished various complex mechanisms, such as clathrin-mediated endocytosis, caveolae-mediated endocytosis and macropinocytosis, which are more challenging to control for pharmaceutical drug delivery scientists

“Hydrophilic polymers as release modifiers for primaquine phosphate: Effect of polymeric dispersion

Primaquine (PQ), a synthetic compound with potent antimalarial activity is characterized by low plasma half life, requiring frequent administration leading to several undesired side effects, patient incompliance. The objective of the present study was to design an extended release formulation incorporating PQ in hydrophillic matrix composed of HPMC,Sodium CMC, Sodium alginate. Effects of polymeric dispersions of ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) was also studied. Tablets were prepared by wet granulation method. The results of angle of repose (<30) and compressiblity index (upto 15%) indicate good flow properties. Tablets were subjected to weight variation, hardness, friability and drug content tests. The swelling and drug release profile were investigated under dissolution condition. The result showed that the swelling index & release retarding capacity follows HPMC>Sodium CMC>Sodium alginate, which was further sustained by polymeric dispersions of EC and PVP. The kinetics of drugs showed extended release of up to 20 hrs (F3) following non fickian diffusion (0.45<n<0.89).

“Submicron-size biodegradable polymer-based Didanosine particles for treating HIV at early stage: an in vitro study

Human immunodeficiency viruses (HIV) hide themselves in macrophages at the early stage of infection. Delivering drug in a sustained manner from polymeric nanoparticles in those cells could control the disease effectively. The study was intended to develop poly(d,l-lactic-co-glycolic acid)-based nanoparticles containing didanosine and to observe their uptake by macrophages in vitro. Various physicochemical evaluations related to nanoparticles, such as drug–excipient interaction, surface morphology, particle size, zeta potential, polydispersity index, drug loading, in vitro drug release and nanoparticle-uptake by macrophages in vitro were determined. Homogenising speeds and drug–polymer ratio varied drug loading and polydispersity index of nanoparticles, providing sustained drug release.

Poly-lactide-co-glycolide nanoparticle containing Voriconazole for pulmonary delivery: in vitro and in vivo study

Poly-lactide-co-glycolide nanoparticles (207-605 nm) containing voriconazole (VNPs) were developed using a multiple-emulsification technique and were also made porous during preparation in presence of an effervescent mixture for improved pulmonary delivery. Pulmonary deposition of the particles was studied using a customized inhalation chamber. VNPs had a maximum of 30% (w/w) drug loading and a zeta potential (ZP) value around -20 mV. In the initial 2 hours, 20% of the drug was released from VNPs, followed by sustained release for 15 days. Porous particles had a lower mass median aerodynamic diameter (MMAD) than nonporous particles. Porous particles produced the highest initial drug deposition (~120 ?g/g of tissue). The drug was detectable in lungs until 7 days and 5 days after administration, for porous and nonporous particles, respectively. VNPs with improved drug loading were successfully delivered to murine lungs. Porous nanoparticles with lower MMADs showed better pulmonary deposition and sustained presence in lungs.

"Potential Applications of Ethiopian natural gums as pharmaceutical excipients: A review"

“Nanobiotechnology-based drug delivery in brain targeting”

“CANCER NANOTHERANOSTICS: A New Paradigm Of Simultaneous Diagnosis And Therapy”

Drug Dose Adjustment Practices in Patients with Renal Impairment at Ayder Referral Hospital, Mekelle, Northern Ethiopia

Social and cultural factors of family influencing the good scholastic performance of school children in rural area, Bhadrak District, Odisha.

“Personal Factors of Students Influencing In the Good Scholastic Performance of School Children In Rural Area, Bhadrak District, Odisha

“Ichthyofaunal Assessment of Birupa River, Odisha, India”

] Phytoremediation of Chromium by Chickpea (Ciecer arietinum L.) and Mung bean (Vigna radiate L.) A comparative study

Geo-Biochemistry of Wetlands in Laterite Mines, the Chilika Catchment , Odisha: GIS Study and XRF-Spectroscopy appraisal

Study and effect of Fungicides to control the fungal contamination of In-Vitro Flowering plant , Anthurium andreanum

Anti-oxidant and HPLC analysis of an Indian Medicinal Herb : Paederia foetida L.(Prasarini)

Evaluation of Antioxidant Properties and GCMS Analysis of Indian Medicinal Herb : Paederia foetida L.(Prasarini)

Ichthyofaunal Assessment of Birupa River, Odisha, India

Cancer nanotheranostics: a new paradigm of simultaneous diagnosis and therapy

Tailor Made Polymeric Nanoparticle: Smart Approaches for Effective Drug Delivery to Tumor Cells

Preventive role of naringin in diabetes mellitus and its mechanism of action : a review

Clinical features and laboratory diagnosis tool for emerging corona virus (covid-19): a review

Annonaine an Alkaloid from the Leaves of Custard Apple (Annona squamosa): A Comprehensive Review on its Phytochemicals and Pharmacological Activities

Annona squamosa is most widely distributed in tropical and subtropical region native to tropical America comes under the Annonaceae family. It is a widely used tree having edible fruits called as custard apple which is eatable. Annona squamosa plant also contains 35-42 mg/100 g of vitamin C and significant value of nutrient like thiamine, amino acid, riboflavin, niacin, calcium, potassium and dietary fibers. It also contains the phytoconstituents like diterpenes, alkaloids, cyclopeptides and annonaceous acetogenins proved by phytochemistry investigations. The plant Annona squamosa show a number of pharmacological activities like insecticidal, anticancer, hypoglycemic, antioxidant, antimalarial, analgesic and wound healing activity. The vermicidal effect of leaves is responsible for the treatment of tumors, wounds and other skin infections. A number of alkaloids were isolated from the leaves of plant. Most of them belong to aporphine group of alkaloids. Among all the phytoconstituents an alkaloid Annonaine, plays a vital role for its biological activity. The present review represents the phytochemical constituents, biological action, traditional as well as medicinal uses of Annona squamosa. Sugar apple might be the better explored plant part used in treatment of many disorders and the present critical study will hopefully provide a disease free and healthy life to the human society.

HAEMO CONDITIONS ASSOCIATED WITH BLOOD GROUP TRANSFUSION

ABO gene is autosomal and to code ABO blood group, every person carries two copies of genes. A series of glycoprotein and glycolipids are present on the surface of human red blood cells with the presence of blood group antigen. Landsteiner in 1901 was discovered ABO blood group as the first human blood
group system and in 1941 Rh blood group was defined by Landsteiner and Wiener. ABO blood group system discover in human was an open way of discovery in the field of immuno hematology and blood transfusion. A person is inherited with one A group gene and with one B group gene, then they posses
both A and B antigen red cells and termed as A,B and O productions of A,B and no O antigens respectively. The gene giving rise to blood group polymorphisms are sufficient to delineate mechanisms of with external agent interaction. From this review, we have concluded that blood group A and O were more proned to have different clinical syndromes. And to create awareness on this blood group associated disorders in the patients and health professionals.

Drug Repurposing-New Age Science of Drug Discovery

Microsponge Drug Delivery System: An Updated Review

Formulation and evaluation of Dispersible Tablet of an Anti-Diarrhoeal Drug

Prevention of COVID-19 with Isolataion in Foreign Travel history- Short Communication Study

Medicinal plants Used as diuretic By the Tranditional Healers in the Ganjam District of Odisha: A review

Cellular and Molecular Mechanism of Liver Fibrosis: A Critical Insight

Analytical QbD based development of a novel RP-UHPLC method for the quantification of albuterol sulphate in its MDI formulations

An overview on ethnopharmacology of different medecinal plants of Odisha in the management of Diabetis mellitus

A comprehensive review on Promising phytopharmacological applications of chamomile flower’

Development of biodegradble polymer based nanoparticles of doxorubicin; an in vitro evaluation,

The promising role of oleanolic acid in the management of diabetes mellitus: A review

Analytical Strategies for the Detection and Quantification of Nano-formulated Antibiotics: Updates and Perspectives

‘Lomustine Incorporated Lipid Nanostructures Demonstrated Preferential Anticancer Properties in C6 11 - Glioma Cell Lines with Enhanced Pharmacokinetic Profile in Mice

Preparation and in-vitro, in-vivo characterisation of Pioglitazone loaded Chitosan/PEG blended PLGA biocompatible nanoparticles

Natural Alkaloids: An Updated Teratological Review on Livestocks

Black Fungus: Pandemic Devastating India?

Pharmaceutical Suspensions: A Review on another Approach for Poorly Soluble Novel Materials

Risk factors, Diagnostic Parameters, and Cellular Identification of Ovarian Malignancy: A Brief Review

A Review on Herbal Formulation in the Management of Vitiligo

Effect of Selected Hydrophilic Polymers on the In Vitro Dissolution Profile of Aceclofenac Crystals

Biomimetics: A novel tool for targeted drug delivery

Bio-electric medicine

Vesicular stomatitis virus glycoprotein as a new gene carrier: Niosomal virosome

Formulation and Characterization of Raloxifene hydrochloride solid dispersion

Potential therapeutic efficacy of catechin: A comprehensive Review

Current Approaches and Challenges of Polymeric Nanoparticles in the Treatment of Brain Tumor

Novel targeting aspects in the management of Hepatic fibrosis: A brief review

Protective effect of Epicatechin in diabetic-induced peripheral neuropathy: a review

Emerging Monkey pox Cases Amid the Ongoing COVID-19 Pandemic in Indian Subcontinent: A Probable Healthcare Challenge for the South East Asia

Review on the use of molecular docking as the first line tool in drug discovery and development

Emerging Monkey pox Deadly Endemic Zoonotic Disease Ebola re-emerges in the Democratic republic of Congo amid the ongoing Covid-19; are we prepared from lesion learnt?- CorrespondenceCases Amid the Ongoing COVID-19 Pandemic in Indian Subcontinent: A Probable Healthcare Challenge for the South East Asia

Rational of Medicinal Ghrita on treatment of CNS disorders

Release profile and cytotoxicity study of modified doxorubicin nanoparticles

Antidiabetic and Antihyperlipidemiceffects of Premna spinosa bark in experimental animal models

Antidiabetic and Antihyperlipidemiceffects of Premna spinosa bark in experimental animal models

Formulation and Contemporary Approach to Mini Tablets: A Review