About Me |
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Looking towards a challenging career where
administrative, teaching and research knowledge & expertise will be
utilized towards the development of the organization
I pursued my Bachelor of
Pharmacy from PES College of Pharmacy, Bangalore in 1996, Master of Pharmacy from
University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, in 2001 and Doctoral degree from
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India. Having over
19 years of UG and PG teaching experience he served various faculty positions
at various Pharmacy Institutions of high repute in Inida and abroad like
National Institute of Pharmaceutical Education & Research (NIPER),
Raebareli, India and College of Health Science, Mekelle University, Ethiopia.
He has presented many papers at several National and International level
Seminars and published many articles in peer reviewed National and
International journals.
Achievements & Contributions:
Organizing Committee Experience 1. Resource person in ICN conference at Kotiyam, Kerala
on 10th April 2021. 2. Convenor in DST-SERB National Seminar on Recent advances and challenges on Forensic crime investigation on 14th and 15th Dec 2019. 3. Local organising Secretary in 3rd PHARM. TECH. IAPST International Conference On Molecular Mechanism Of Diseases And Novel Therapeutic Approaches†On 19 & 20 January, 2019 4. Delivered guest talk in QIP short term program on 19/03/2018 at UDPT, Jadavpur University, Kolkata. 5. Convenor in the ICMR sponsored National Seminar on dt 4th and 5th March 2018 at CUTM, Bhubaneswar 6. Member of the Registration Committee of the 1st Pharm Tech - IAPST International Conference on Drug Delivery and Drug Targeting Research†to be held on 19th and 20th of January, 2008 at Jadavpur University, Kolkata. 7. Organizing and co-ordinating QIP Refreshersâ Programme for the session July- August 2007, January 2008, August- September 2008, January 2009 and July- August 2009 continuing at the Department of Pharmaceutical Technology, Jadavpur University, Kolkata. 8. Member of Editorial board in the annual magazine of NIPER, Raebareli published on 14th November 2009. 9. Member of organizing Scientific committee at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25th-27th, 2010.
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[1] Preparation, characterization and in-vitro evaluation of sustain release protein loaded nanoparticle based on biodegradable polymers.Biswajit Mukherjee, Kousik Santra, Gurudutta Pattnaik, Soma Ghosh. Dept of Pharm Tech, Jadavpur University, Kolkata. International Journal of Nanomedicine 2008: 3(4) 487-496. (Impact factor- 4.976)
[2] “Pulmonary Drug Dellivery System: A Novel Approachâ€. Akhilesh Viswakarma, G D Pattnaik*, Md. Tahir Ansari, Md. Sajid Alli. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER). Inventis Rapid: NDDS. 2010 vol.1, Issue 1.
[3] “Self-Emulsifying Drug Delivery Systems: An Attempt To Improve Oral Absorption Of Poorly Soluble Drugsâ€. Pattnaik Gurudutta*, Parmar Jeetesh, Ali M Sajid, Ansari M Tahir Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), India. Research Journal of Pharmaceutical Dosage Form And Technology (RGPDFT) 2 (3): May- June 2010, 103-108.
[4] “Preparation and invivo evaluation of sustained release matrix tablets of phynytoin sodium using natural polymerâ€. MA Sajid , S Swati, S Sant, K Awadhesh, Pattnaik G D, Tahir MA. Dept of pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh 229010, India. International Journal of Pharmacy and Pharmaceutical Sciences. (May-June 2010 ).
[5] “Optimization of fast disintegrating tablets for diclofenac sodium using isabgol mucilage as superdisintegrant†MA Tahir1*,K Awadhesh1, S Swati1, S Sant1,, MA Sajid1, G D Pattnaik 1, Farheen 2. 1. Department of pharmaceutics, National institute for pharmaceutical education and research, Raebareli, Uttar pradesh, India, 229010, 2. Azad institute for pharmacy and research, Lucknow, Uttar Pradesh, India. International Journal of Pharmaceutical Sciences. (May-August 2010; 2(2)).
[6] “Comparative studying on various tableting properties of phenytoin sodium mouth dissolving dosage form using spherical crystals.†Asad Nafis, Rama Raju, Tahir Ansari, Sajid Alli, G D Pattnaik. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Raebareli (U.P.), India. International Journal of Pharmaceutical Science and Technology.Vol-5, Issue-2,2010.
[7] “Nanosuspension: An Attempt To Enhance Bioavailability of Poorly Soluble Drugs†Heeralal Banavath, Sivarama Raju k, Md. Tahir Ansari, Md. Sajid Ali, Gurudutta Pattnaik*. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Raebareli (U.P.), India. International Journal Pharmaceutical Science and Research (IJPSR) (2010), Vol.1, Issue 9.
[8] "Nanovehicles: An efficient carrier for active molecucles for entry in to the cell" Gurudutta Pattnaik*, K Siva Rama Raju, B Heeralal, Md. Sajid Ali. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Raebareli (U.P.), India. International Journal of Pharmaceutical Sciences review and research, Volume 4, Issue 3, September-October 2010. (Impact factor- 0.65)
[9] “Hydrophilic polymers as release modifiers for primaquine phosphate: Effect of polymeric dispersion.†Sant S1, Swati S1, Awadhesh K1, Sajid MA1, Pattnaik GD1, Tahir MA*1, Farheen S2 1.Department of pharmaceutics, National institute for pharmaceutical education and research, Raebareli, Uttar pradesh, India, 229010, 2. Azad institute for pharmacy and research, Lucknow, Uttar Pradesh, India. ARS Pharmaceutica. 2011; 52(3):19-25. ( Impact factor- 0.51)
[10] “Submicron-size biodegradable polymer-based Didanosine particles for treating HIV at early stage: an in vitro studyâ€. Pattnaik, Gurudutta; Sinha, Biswadip; Mukherjee, Biswajit ; Ghosh, Saikat; Basak, Sandip; Mondal, Subhasis; Bera, Tanmoy Department of Pharmaceutical Technology, Jadavpur University, Kolkata. Journal of Microencapsulation. Received on 3 Nov 2011 Accepted 19 Mar 2012. Early online , 1-11 (Impact factor- 2.0)
[11] “Poly-lactide-co-glycolide nanoparticle containing Voriconazole for pulmonary delivery: in vitro and in vivo study†Sinha, Biswadip; Mukherjee, Biswajit, Pattnaik, Gurudutta; Department of Pharmaceutical Technology, Jadavpur University, Kolkata. Nanomedicine: Nanotechnology, Biology, and Medicine.Received 17th Aug 2011, Accepted 28th Apl 2012, Published on line 24th may 2012. 9 (2013) 94–104. (Impact factor- 7.647)
[12] “Assay method development and validation of ibuprofen tablets by HPLC†Sovan Pattanaik1*, Sangeeta Mukhi1, Gurudutta Pattnaik2 and Jasmin Panda3 1School of Pharmaceutical Sciences, Siksha ‘O’Anusandhan University, Bhubaneswar,2College of Pharmaceutical Science,Puri, 3 Hitech College of Pharmacy, Bhubaneswar, Odissa, India. Pelagia Research Library Der Pharmacia Sinica, 2013, 4(4):91-96.
[13] "Potential Applications of Ethiopian natural gums as pharmaceutical excipients: A review"
Fantahun Molla*, Gurudutta Pattnaik, Abrham Wondimu, Ebisa Tadese, Zewdu Yilma, Ameha Seleshi, Noad G Samuel, Admassu Assen, Solomon Abrha. Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. International Journal of Pharmacy Education and Research, Apr-Jun 2014; 1(2): 1-8.
[14]“Nanobiotechnology-based drug delivery in brain targeting†Subash Chandra Dinda, Gurudutta Pattnaik; Department of Pharmaceutics, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. Current Pharmaceutical Biotechnology. 2013, 14, 1264-1274 (Impact factor- 2.6)
[15] “CANCER NANOTHERANOSTICS: A New Paradigm Of Simultaneous Diagnosis And Therapy†Berihun Sisay, Solomon Abrha, Zewdu Yilma, Admassu Assen, Fantahun Molla, Ebisa Tadese, Abrham Wondimu, Naod Gebre-Samuel, Gurudutta Pattnaik. Department of Pharmaceuticy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. Journal of Drug Delivery & Therapeutics; 2014, 4(5), 79-86.
[16] “Drug Dose Adjustment Practices in Patients with Renal Impairment at Ayder Referral Hospital, Mekelle, Northern Ethiopia†Kidu Gidey, Naod Gebre-Samuel, Fantahun Molla*, Solomon Abrha, Abrham Wondimu, Admassu Assen, Wondim Melkam, Gurudutta Pattnaik.
Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. Int. J. Pharm. Sci. Rev. Res., 30(2), January – February 2015; Article No. 27, Pages: 153-157
[17] Social and cultural factors of family influencing the good scholastic performance of school children in rural area, Bhadrak District, Odisha. Rashmirekha Sahu, Dr Narendra Behera, Dr Gurudutta Pattnaik, School of Pharmacy and life Sciences, Centurion University of Technology and Management, International Journal of Engineering Development and Research. Bhubaneswar. Volume 6, Issue 2 April 2018, 145-148.
[18] “Personal Factors of Students Influencing In the Good Scholastic Performance of School Children In Rural Area, Bhadrak District, Odisha†Rashmirekha Sahoo, Dr Narendra Behera, Dr Soumya Ranjan Mohanty, Dr Gurudutta Pattnaik, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar. International Journal of Science & Research (IJSR), DOI: 10.21275/ART20181667 Volume 7, Issue 4, April 2018.
[19] “Ichthyofaunal Assessment of Birupa River, Odisha, India†Aradhana Khuntia, Trilochan Swain, Gurudutta Pattnaik. School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar. Journal of Emerging Technologies and Innovative Research (JETIR). Volume 5, Issue 5.May 2018.
[20] Phytoremediation of Chromium by Chickpea (Ciecer arietinum L.) and Mung bean (Vigna radiate L.) A comparative study. Saibalini Behera, SuryakantaBahira, Gurudutta Pattnaik and Puspashree Puhan, School of Pharmacy and life sciences, Centurion University of Technology and Management, Bhubaneswar. International Journal of Current Science Research. Volume 4, Issue 6, June 2018, 1589-1598, ISSN: 2454-5422.
List of papers presented:
[1] Role of hydrophilic and hydrophobic polymers on Zudovudine release from modified release tablets at AICTE sponsored national seminar- 2010 âThe changing face of pharmaceutical research in present global scenario’ at School of pharmaceutical sciences, Siksha o Anusandhan University, Bhubaneswar, Odisha, India on 30th & 31st December 2010.
[2] Development of Floating drug delivery system of H2 blocker drug by emulsification followed by gelatinous technique at AICTE sponsored national seminar- 2010 ‘The changing face of pharmaceutical research in present global scenario’ at School of pharmaceutical sciences, Siksha o Anusandhan University, Bhubaneswar, Odisha, India on 30th & 31st December 2010.
[3] Formulation and development of fast disintegrating tablets for Diclofenac sodium using plant product Plantago ovata mucilage as Super disintegrant at AICTE sponsored national seminar- 2010 ‘The changing face of pharmaceutical research in present global scenario’ at School of pharmaceutical sciences, Siksha o Anusandhan University, Bhubaneswar, Odisha, India on 30th & 31st December 2010.
[4] Development of rapidly disintegrating tablets of H1 antagonist like Loratidine at AICTE sponsored national seminar- 2010 ‘The changing face of pharmaceutical research in present global scenario’ at School of pharmaceutical sciences, Siksha o Anusandhan University, Bhubaneswar, Odisha, India on 30th & 31st December 2010.
[5] Influence of excipients at a constant compression force on the release of NSAID from matrix tablets at AICTE sponsored national seminar- 2010 ‘The changing face of pharmaceutical research in present global scenario’ at School of pharmaceutical sciences, Siksha o Anusandhan University, Bhubaneswar, Odisha, India on 30th & 31st December 2010.
[6] Formulation and Evaluation of Floating gel beads of Ranitidine hydrochloride by emulsion gelation technique at National seminar on drug and drug delivery research : A recent advancement at Centre for advance research in pharmaceutical sciences, Department of pharmaceutical technology, Jadavpur University, Kolkata, India on dt 3rd December 2010.
[7] Development of nanoparticle delivery system of didanosine at National seminar on drug and drug delivery research : A recent advancement at Centre for advance research in pharmaceutical sciences, Department of pharmaceutical technology, Jadavpur University, Kolkata, India on dt 3rd December 2010.
[8] Wound healing activity of methanolic extract of Cissus quandrangularison Albino rat at National seminar on drug and drug delivery research : A recent advancement at Centre for advance research in pharmaceutical sciences, Department of pharmaceutical technology, Jadavpur University, Kolkata, India on dt 3rd December 2010.
[9] Formulation and In vitro evaluation of rapidly disintegrating tablets of Loratidine at National seminar on drug and drug delivery research : A recent advancement at Centre for advance research in pharmaceutical sciences, Department of pharmaceutical technology, Jadavpur University, Kolkata, India on dt 3rd December 2010.
[10] Application of complemetary polymers in HPMC in hydrophilic extended release matrices at National seminar on drug and drug delivery research : A recent advancement at Centre for advance research in pharmaceutical sciences, Department of pharmaceutical technology, Jadavpur University, Kolkata, India on dt 3rd December 2010.
[11] Optimization of fast disintegrating tablet for diclofenac sodium using Isabgol mucilage as super disintegrant at National seminar on drug and drug delivery research : A recent advancement at Centre for advance research in pharmaceutical sciences, Department of pharmaceutical technology, Jadavpur University, Kolkata, India on dt 3rd December 2010.
[12] Influence of type and content of excipient and compression force on the release of Indomethacin from a low viscosity grade of Hydroxypropyl methylcellulose matrix tablets at National seminar on drug and drug delivery research : A recent advancement at Centre for advance research in pharmaceutical sciences, Department of pharmaceutical technology, Jadavpur University, Kolkata, India on dt 3rd December 2010.
[13] Development of Spherical Crystallization Method to improve Direct Compressibility of Phenytoin Sodium at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[14] DMPK studies in drug discovery and preclinical development at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[15] Preparation, characterization and in-vitro evaluation of sustained release model protein loaded microparticles based on PLGA. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[16] Ecofriendly spectrophotometeric estimation of diclofenac sodium using N,N- Dimethylurea as Hydrotropic agent. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[17] Effect of different disintegrating agents and their concentration on the disintegration time and dissolution time of mouth dissolving tablets. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[18] Fast dissolving buccal films of Levocetirizine dihydrochloride. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[19] Microsphere preparation by emulsion solvent evaporation method: A study of process variable. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[20] Microspheres in Cancer Therapy. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[21] Development and validation of a simple stability-indicating high performance liquid chromatographic method for the determination of natamycin in bulk and pharmaceutical dosage form. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[22] Once daily sustained release matrix tablets of primaquine: formulation and evaluation. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[23] Optimization of fast disintegrating tablets of diclofenac sodium using isabgol mucilage as natural superdisintegrant. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[24] Preparation and in-vitro Evaluation of Sustained Release Matrix Tablets of phenytoin sodium using Natural Polymers. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[25] Self-Emulsifying Drug Delivery Systems: An attempt to improve oral absorption of poorly soluble drug. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical
Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[26] Solid Lipid Nanoparticles: Preparation & Characterization. at 2nd NIPER-CDRI Symposium on Medicinal Chemistry & Pharmaceutical Sciences Venue at CDRI, Lucknow from March 25-27, 2010.
[27] ‘An Efficient Volumetric Heating Technique to Optimize Heat Transfer Processes During Vial Freeze- Drying’ at 1st Pharm Tech International Conference held at Jadavpur University, Kolkata on 19th January and 20th January 2008.
[28] ‘Development of Rosiglotazone containing Transdermal Matrx patches Based on pressure sensitive adhesive polymers’, at 1st Pharm Tech International Conference held at Jadavpur University, Kolkata on 19th January and 20th January 2008.
[29] ‘Preparation and Characterization of parenterally Administrable Microparticles Containing Protein, Ovalumin as a Model Drug’ at 1st Pharm Tech International Conference held at Jadavpur University, Kolkata on 19th January and 20th January 2008.
[30] ‘Microparticulate protein Delivery System Containing Ovalumin as a Model Drug’ at 95th Indian Science Congress held at Visakhapatnam, A.P from 3rd January 2008 to 7th January 2008
[31] ‘Nanoparticulate protein delivery system containing Bovine Serum Albumin as a model drug’. at 59th IPC held at Banaras from 20th to 23rd Dec 2007.
[32] ‘Development of Dexamethasone containing Liposomal vesicles based on different combination of lecithin and cholesterol’ at 1st IAPST annual national convention held at Gopalpur, Orissa on 18th November 2007.
[33] ‘Formulation and Evaluation of Isopropyl Antipyrine Gel’ at 54th IPC held at Pune in Biopharmaceutics session from 13th to 15th Dec 2002.
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Controlled drug delivery technology of proteins/peptides from biodegradable nanoparticles has emerged as one of the eminent areas to overcome formulation associated problems of the macromolecules. The purpose of the present investigation was to develop protein-loaded nanoparticles using biodegradable polymer poly l-lactide-co-glycolidic acid (PLGA) with bovine serum albumin (BSA) as a model protein. Despite many studies available with PLGA-based protein-loaded nanoparticles, production know-how, process parameters, protein loading, duration of protein release, narrowing polydispersity of particles have not been investigated enough to scale up manufacturing of protein-loaded nanoparticles in formulations. Different process parameters such as protein/polymer ratio, homogenizing speed during emulsifications, particle surface morphology and surface charges, particle size analysis and in-vitro
Self emulsifying drug delivery systems (SEDDS) have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. The oral route of drug delivery is typically considered the preferred and most patient convenient means of drug administration. However, more than 40% of new chemical entities exhibit poor aqueous solubility. SEDDS have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SEDDS are isotropic mixtures of oils and surfactants, sometimes containing cosolvents, and can be used for the design of formulations in order to improve the oral absorption of highly lipophilic compounds. In SEDDS mixture of hydrophobic drug, surfactant with or without cosurfactant is mixed and then formulated either in soft gelatin capsule or in hard gelatin capsule. After administering the drug by this system, emulsion is formed in the GIT with aqueous GI fluied due to peristaltic movement of GIT
The aim of the present study was to develop sustained release matrix tablets of phenytoin sodium an antiepileptic drug. Advantages of sustained-release tablets are that they can often be taken less frequently than instant release formulations of the same drug, and that they keep steady levels of the drug in the blood stream. The tablets were fabricated by the wet granulation method using water as granulating agent along with matrix materials like guar gum, sodium alginate, tragacanth and xanthan gum with varying percentage. The granules were evaluated for angle of repose, bulk density, compressibility index, total porosity, and drug content. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. The swelling behavior of matrix was also investigated. The granules showed satisfactory flow properties, compressibility, and drug content. The IR spectral analysis studies confirmed no interaction between phenytoin with used natural gums. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters.
Fast disintegrating tablets used for administration in the oral cavity were prepared either by direct compression or by wet granulation method. The The disintegration time of conventional tablets was reduced from 10 minutes to a minimum of 23 seconds by introducing 2-5% of dried isabgol extract. By optimizing moisture content of the granules, tablets meeting tensile strength greater than 0.6 MPa and disintegration time shorter than 100 s were obtained by the wet compression method. The tensile strength of the tablet increased remarkably in tablets prepared by wet granulation process, while the porosity of the tablet seemed almost unchanged. Superdisintegrant features of isbagol was further optimized by water absorption and in vitro dispersion time. Wetting time and disintegration time matched with the requirements of EP, Dissolution profiles suggested that the superdisintegrants action of the dried isabgol mucilage enhanced the release of the drug from tablets with respect to conventional marketed. Moreover, Directly compressed tablets released drug rapidly as compared to wet granulation process.
The aim of the present study was to develop sustained release matrix tablets of phenytoin sodium an antiepileptic drug. Advantages of sustained-release tablets are that they can often be taken less frequently than instant release formulations of the same drug, and that they keep steady levels of the drug in the blood stream. The tablets were fabricated by the wet granulation method using water as granulating agent along with matrix materials like guar gum, sodium alginate, tragacanth and xanthan gum with varying percentage. The granules were evaluated for angle of repose, bulk density, compressibility index, total porosity, and drug content. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. The swelling behavior of matrix was also investigated. The granules showed satisfactory flow properties, compressibility, and drug content. The IR spectral analysis studies confirmed no interaction between phenytoin with used natural gums. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters
Most of the new chemical entities coming out from Highthroughput screening in drug discovery process are failing due to their poor solubility in the water. Poorly water-soluble drugs show many problems in formulating them in conventional dosage forms. One of the critical problems associated with poorly soluble drugs is too low bioavailability. The problem is even more complex for drugs belonging to BCS CLASS II category, as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2. There are number of formulation approaches to resolve the problems of low solubility and low bioavailability. These techniques for solubility enhancement have some limitations and hence have limited utility in solubility enhancement. Nanotechnology can be used to resolve the problems associated with these conventional approaches for solubility and bioavailability enhancement. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10-9 meters. The present article describes the details about nanosuspensions. Nanosuspensions consist of the pure poorly water-soluble drug without any matrix material suspended in dispersion.
Nanovehicle as a carriers offer exclusive possibilities to overwhelmed cellular obstruction in order to improve the delivery of active substances, including the promising therapeutic biomacromolecules (i.e., nucleic acids, proteins). There are number of mechanisms lead to nanocarrier cellular internalization that is desperately affected by nanoparticles’ physicochemical properties. The pharmacological actions of nanocarriers may be depends on the different paths cellular uptake and intracellular trafficking. In this article we are trying to foccus on several opportunities, starting with the phagocytosis pathway, which has followed in the treatment of certain cancer and various infectious diseases. On the other side, the non-phagocytic pathways accomplished various complex mechanisms, such as clathrin-mediated endocytosis, caveolae-mediated endocytosis and macropinocytosis, which are more challenging to control for pharmaceutical drug delivery scientists
Primaquine (PQ), a synthetic compound with potent antimalarial activity is characterized by low plasma half life, requiring frequent administration leading to several undesired side effects, patient incompliance. The objective of the present study was to design an extended release formulation incorporating PQ in hydrophillic matrix composed of HPMC,Sodium CMC, Sodium alginate. Effects of polymeric dispersions of ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) was also studied. Tablets were prepared by wet granulation method. The results of angle of repose (<30) and compressiblity index (upto 15%) indicate good flow properties. Tablets were subjected to weight variation, hardness, friability and drug content tests. The swelling and drug release profile were investigated under dissolution condition. The result showed that the swelling index & release retarding capacity follows HPMC>Sodium CMC>Sodium alginate, which was further sustained by polymeric dispersions of EC and PVP. The kinetics of drugs showed extended release of up to 20 hrs (F3) following non fickian diffusion (0.45<n<0.89).
Human immunodeficiency viruses (HIV) hide themselves in macrophages at the early stage of infection. Delivering drug in a sustained manner from polymeric nanoparticles in those cells could control the disease effectively. The study was intended to develop poly(d,l-lactic-co-glycolic acid)-based nanoparticles containing didanosine and to observe their uptake by macrophages in vitro. Various physicochemical evaluations related to nanoparticles, such as drug–excipient interaction, surface morphology, particle size, zeta potential, polydispersity index, drug loading, in vitro drug release and nanoparticle-uptake by macrophages in vitro were determined. Homogenising speeds and drug–polymer ratio varied drug loading and polydispersity index of nanoparticles, providing sustained drug release.
Poly-lactide-co-glycolide nanoparticles (207-605 nm) containing voriconazole (VNPs) were developed using a multiple-emulsification technique and were also made porous during preparation in presence of an effervescent mixture for improved pulmonary delivery. Pulmonary deposition of the particles was studied using a customized inhalation chamber. VNPs had a maximum of 30% (w/w) drug loading and a zeta potential (ZP) value around -20 mV. In the initial 2 hours, 20% of the drug was released from VNPs, followed by sustained release for 15 days. Porous particles had a lower mass median aerodynamic diameter (MMAD) than nonporous particles. Porous particles produced the highest initial drug deposition (~120 ?g/g of tissue). The drug was detectable in lungs until 7 days and 5 days after administration, for porous and nonporous particles, respectively. VNPs with improved drug loading were successfully delivered to murine lungs. Porous nanoparticles with lower MMADs showed better pulmonary deposition and sustained presence in lungs.
Annona squamosa is most widely distributed in tropical and subtropical region native to tropical America comes under the Annonaceae family. It is a widely used tree having edible fruits called as custard apple which is eatable. Annona squamosa plant also contains 35-42 mg/100 g of vitamin C and significant value of nutrient like thiamine, amino acid, riboflavin, niacin, calcium, potassium and dietary fibers. It also contains the phytoconstituents like diterpenes, alkaloids, cyclopeptides and annonaceous acetogenins proved by phytochemistry investigations. The plant Annona squamosa show a number of pharmacological activities like insecticidal, anticancer, hypoglycemic, antioxidant, antimalarial, analgesic and wound healing activity. The vermicidal effect of leaves is responsible for the treatment of tumors, wounds and other skin infections. A number of alkaloids were isolated from the leaves of plant. Most of them belong to aporphine group of alkaloids. Among all the phytoconstituents an alkaloid Annonaine, plays a vital role for its biological activity. The present review represents the phytochemical constituents, biological action, traditional as well as medicinal uses of Annona squamosa. Sugar apple might be the better explored plant part used in treatment of many disorders and the present critical study will hopefully provide a disease free and healthy life to the human society.
ABO gene is autosomal and to code ABO blood group, every person carries two copies of genes. A series of glycoprotein and glycolipids are present on the surface of human red blood cells with the presence of blood group antigen. Landsteiner in 1901 was discovered ABO blood group as the first human blood
group system and in 1941 Rh blood group was defined by Landsteiner and Wiener. ABO blood group system discover in human was an open way of discovery in the field of immuno hematology and blood transfusion. A person is inherited with one A group gene and with one B group gene, then they posses
both A and B antigen red cells and termed as A,B and O productions of A,B and no O antigens respectively. The gene giving rise to blood group polymorphisms are sufficient to delineate mechanisms of with external agent interaction. From this review, we have concluded that blood group A and O were more proned to have different clinical syndromes. And to create awareness on this blood group associated disorders in the patients and health professionals.