About Me |
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I am working as a faculty in CUTM,Balsore now. I have done Ph.D. from Berhampur University, Berhampur,Odisha,India , Master in Pharmaceutics from Biju Patnaik University of Technology,Odisha and Bachelor in Pharmacy from Berhampur University.I have about teaching experience 14 years and few months.I have work experience in different field in Pharmacy like Dispensing Pharmacy,Physical Pharmacy,Industrial Pharmacy,Biopharmaceutics and Pharmacokinetics,Pharmaceutical Biotechnology, Novel Drug Delivery systems, Pharmaceutical Jurisprudence,HAP etc. |
- New drug delivery system
- formulation design
- sustained drug delivery
- Dispensing Pharmacy
- Physical Pharmacy
- Industrial Pharmacy
- Pharmaceutical Jurisprudence
- Pharmaceutical Biotechnology
- New drug delivery system
- formulation design
- Academic
- reasearch and development
Research Fields
1.Floating Tablet
2.Colon specific drug delivery system
Recent Publications (International Journals)
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Academic Honors & Awards
Formulation and In-Vitro Evaluation of Floating Tablet of Gabapentin
The present research work is an attempt to formulate rate controlled drug delivery system of Gabapentin which is primarily absorbed from stomach, so by increasing the GRT of the drug, the bioavailability can be increased. As the drug is stable in acidic pH and mostly absorbed with in pH 1–3, as the stomach is the major absorption site for the drug. Basing on this fact the drug is made to float in the stomach using the mechanism of buoyancy. The study also includes various evaluation studies of Gabapentin tablet and the effect of processing variables on it. A possible interaction between drug and polymers are also investigated by FTIR and DSC studies. So, the present work has been under taken with the objective of designing and evaluation of floating oral sustained release tablet drug delivery system of Gabapentin by using HPMC K15, NaCMC, Xanthun gum, sodium bicarbonate, citric acid. Lactose, ethyl cellulose.
Formulation and in vitro Characterization of Metronidazole Loaded Polymeric Microspheres for Colon Specific and Sustained Drug Delivery.
Objective:
Metronidazole stacked alginate microspheres have been utilized to drag out the gastric living arrangement time and enhance the neighbourhood impact of medication in the district of colon for the treatment of bacterial contaminations by expecting that the colonic microbes will enzymatically corrupt the polysaccharide into natural corrosive and by bringing down the pH condition with the goal that disintegration of corrosive dissolvable covering and arrival of medication occur at the same time.Methods:
Metronidazole microspheres were made by ionic gelation method utilizing Guargum, Chitosan, Eudragit S-100 and sodium alginate at various proportions and utilized calcium chloride (4% w/v) as rigidizing operator. Microspheres were described for its molecule measure, medicate stacking, tranquilize capture, swelling file and medication discharge properties.Results:
Microspheres are observed to be inside size extents from 36.77 µm to 229.96 µm with medication capture proficiency of 42–99% w/w. The microsphere kept up to maintain the medication discharge up to 12 h if there should be an occurrence of definition FG4. Medication discharge from the microspheres, swelling file and lightness establishes to be relies upon the grouping of chosen polymers in the polymer mixture. Definitions containing low groupings of Guargum, Chitosan, Eudragit S-100 and sodium alginate (1: 1) demonstrating shorter drifting slack time and quicker medication discharge and the other way around. Accordingly, swelling record and rate of medication discharge seemed, by all accounts, to be balanced by the centralization of chose polymers in the polymer …Formulation design and characterization of colon-targeted mesalamine microspheres and their biodistribution potential study in mice
Aim:
The aim of this study is to design formulations of mesalamine microspheres (MMS) for the treatment of Crohn’s disease and ulcerative colitis in the colon.Materials and Methods:
Emulsification solvent diffusion method was employed for the preparation of MMS coated with Eudragit RS/ES-100 to prevent the drug release in the stomach. The prepared microspheres were characterized for surface morphology, drug entrapment efficiency, drug loading, and in vitro drug release study.Results and discussion:
The micromeritic studies showed that the prepared microspheres had improved flowability. The result obtained was found in the desired ranges, where percentage yield ranging from 65.75% to 67.46%, drug entrapment efficiency from 83.02% to 86.42%, and mean particle size ranges from 6.99 ?m to 15.37 ?m. Scanning electron microscopy permitted a surface topographical analysis. From the biodistribution study, it can be observed that AUC0–t of the microspheres was 2.63-folds greater than the solution (P< 0.05) in the colon.Conclusion:
The study reveals that drug release was significant at pH 7.4 from the microspheres at colon region, so the drug will be better absorbed in colon and can be used for successful treatment of the Crohn’s disease and ulcerative colitisCOLON SPECIFIC DRUG DELIVERY SYSTEM: AN APPROACH TO TARGET COLONIC DISEASES
Drug as such, may not show the desired therapeutic effect;
drug delivery is the method or process of administering a pharmaceutical
compound to achieve a therapeutic effect in humans or animals. Targeted
drug delivery into the colon is highly desirable for local treatment of a
variety of bowel diseases such as ulcerative colitis, Crohn’s disease,
amoebiasis, colonic cancer, local treatment of colonic pathologies, and
systemic delivery of protein and peptide drugs. Colon targeted drug
delivery system (CTDDS) can deliver drugs as both local and systemic.
Local delivery, in the treatment of inflammatory bowel disease (IBD).
Treatment could be enhanced when drug delivered to the target site on the
colon. Systemic side effects could also be reduced. Colon-specific
systems are the most important delivery of those drugs which are
normally inactivated in the upper parts of the gastrointestinal tract (GIT).
Primary approaches for CTDDS (Colon Targeted Drug Delivery System),
which includes prodrugs, pH and time-dependent systems, bacterial
enzyme dependent colonic DDS and pH and bacterial enzyme dependent
colonic DDS. The novel approach of CTDDS, which includes pressure
controlled colonic delivery capsules (PCDCS), osmotic controlled drug
delivery are specific techniques.
Production and Applications of Radiopharmaceuticals: A Review
Radiopharmaceuticals are exclusive medicinal formulations including radioisotopes which are utilized in foremost clinical areas for study, diagnosis
and/or therapy. They are radioactive agents employed in nuclear medical
field to demonstrate high and exact localization radioactivity into target
tissue. Recently, however, there has been a considerable development of
this division of nuclear medicine with the preamble of a quantity of new
radionuclides and radiopharmaceuticals for the treatment of cancer, neuroendocrine disorder and other diseases. The application of definite radiotracers
called radiopharmaceuticals for imaging organ function and disease states
is an exceptional potential of nuclear medicine. Distinct other imaging
modalities, for example- Computed Tomography (CT), Magnetic Resonance
Imaging (MRI) and Ultrasonography (US), nuclear medicine procedures are
competent of drawing physiological function and metabolic activity and
thus giving more precise information about the organ function and
dysfunction. This review focuses the production and therapeutic applications of radiopharmaceuticals which hold functional radio atoms.
Effect of Cross Linking on Evaluation of Chitosan Coated Pellets of Glipizide
The objective of the current work is to develop and evaluate the effect of cross linking on drug release of chitosan pellets of Glipizide. Hence the
present work was aimed to formulate glipizide pellets with a view to achieve and to maintain the plasma concentration for considerable period
by controlling the release so to decrease the occurrence of doses and also to recover the patient fulfillment. Here the pellets of glipizide are
designed by Pan Coating technique with solution layering with and without cross linking by Gluteraldehyde effectively. Then the optimized
formulations are aimed to study the effects of polymer and cross linking on different evaluation parameters including the drug release study.
Finally the conclusion was to arrive at better formulation based on comparison amongst the studied ones.
Chitosan Based Drug Delivery Systems: A Review
Floating Drug Delivery Systems: A Review
A Review on Targeting of Drugs to Brain
A REVIEW ON INFLAMMATORY BOWEL DISEASE-RECENT PHARMACEUTICAL APPROACHES TO COMBAT IT
Inflammatory bowel diseases (IBD) are chronic and
relapsing intestinal inflammatory conditions, hallmarked by a
disturbance in the bidirectional interaction between gut and brain. IBD
is Ulcerative colitis (UC) and Crohn‘s disease (CD). Conventional
therapies are inadequate and are associated with several systemic side
effects due to lack to localization of active moiety at the inflamed site.
Treatment option range from small molecules to macromolecules
(peptides, proteins and oligonucleotides) that target multiple
therapeutic pathways, and dosed via injectable, oral or the rectal route
for local bowel treatment. Conventional therapies are inadequate and
are associated with several systemic side effects due to a lack of
localization of active moiety at the inflamed site. But colonic drug
targeting is a novel, potentially active area of research intended and
focused on drug delivery for treating localized disease. Targeted drug
delivery to the colon would ensure direct treatment at the disease site,
lower dosing, and fewer systemic side effects
NIOSOMAL DRUG DELIVERY SYSTEM: AN OVERVIEW
Drug delivery systems are defined as formulations aiming for transportation of a drug to the desired
area of action within the body. Carrier-based drug delivery methods are critical because they protect
the medication from rapid breakdown or removal and so increase drug concentration in target
tissues. The biodegradability, biocompatibility, and nonimmunogenicity of niosomes, which are
formed in an aqueous phase by the self-association of nonionic surfactants and cholesterol, makes
them an appealing drug delivery system. In recent years, several research in peer-reviewed
publications have demonstrated the potential of niosomes as a drug delivery method. Niosomal drug
delivery systems are discussed in this review, along with the most recent studies on the topic and
examples of how they have been put to use.
LIPOSOMAL DRUG DELIVERY SYSTEM: AN OVERVIEW
Liposomes were the first nanoscale drug to be approved for clinical use in 1995.A major
advancement in liposome-based delivery methods has been made since that time, and these
advancements have important therapeutic consequences. For example, this comprises liposomes that
can remain in the body for a lengthy period of time, liposomes that can be nebulized and elastic
liposomes that can be used for topical, oral, and transdermal distribution. In contrast to liposomes,
existing guidance on novel delivery strategies has not been well-documented. Liposomal delivery
systems are described in detail, along with the regulatory landscape surrounding commercialization
efforts for higher-level complexity systems, expected requirements, and obstacles faced by
companies looking to bring novel liposome-based systems to market for clinical use, in this in-depth
assessment.
A Textbook of Pharmaceutical Analysis
An insight of development and validation of bio-analytical method in the reference of anti?diabetic drugs by using LC-MS/MS
Diabetes mellitus, which has high rates of disability and
mortality, is one of the main causes of public health concerns
worldwide. It currently poses serious medical and societal issues.
Different bio-analytical techniques have been developed to identify the
pharmaceutical formulation of the anti-diabetic drug. Due to the
continual requirement to achieve improved sensitivity, accuracy, and
speed of analysis in complex biological samples, the development of
bio-analytical sample preparation techniques has grown more difficult
over time (e.g., blood, serum, plasma, saliva, feces, and urine). This is
a mini review, and its goal is to analyze how LC-MS/MS has been
used to for the pharmaceutical formulation of the anti-diabetic
drugs. The method was validated for linearity, accuracy, precision,
specificity, selectivity, and stability.
Text Book of Pharmaceutical Formulation Development
Phytochemical Constituent And Its Pharmacological Application Of Various Types Of Chemical Compounds Present In Cocculus Hirsutus (L.) Diels
This review gives a complete overview of the Cocculus hirsutus (L.) vegetation of Cocculus species
(Synonym-Cocculus villosus, Family: Menispermaceae). Numerous phytoconstituents such as
alkaloids, phenolic compounds, glycosides, and steroids are present mainly in leaves. Even though the
fact that it is frequently used in conventional treatments for conditions including fever, malaria, joint
discomfort, and skin conditions as a diuretic, laxative, and antiperiodic. The manufacturing of
formulations has only been the subject of a very small number of studies. In the future, a welldeveloped formulation based on topical preparation and in-vivo investigations will be required, coupled
with bioassay-guided studies to extract and identify the active ingredients, to demonstrate the
formulation with good pharmacological activity of C. hirsutus plants.
Osmotically Controlled Drug Delivery Systems: A Review
The current review sought to develop an osmotic drug delivery system for regulated drug release. The
oral route of drug delivery is the most prevalent and appropriate approach. Because recurrent dosage
administration is necessary for the treatment of chronic illnesses, the osmotic drug delivery system serves
as a tool for controlling drug release in these conditions and avoiding repetitive administration. The
following review explains the fundamentals of osmotic drug delivery systems, types with a special
emphasis on controlled porosity osmotic pumps, osmosis mechanism, ideal drug candidate, formulation
techniques, various osmotic agents, pore formers, coating materials, and marketed preparations based on
osmotic drug delivery systems. These factors may be useful in designing dose for modifying the release
of different drugs that have a difficulty in their conventional form.
Secondary Qualitative and Quantitative Data Analysis of Formulation Optimization of Drug in Transdermal Drug Delivery System
The transdermal drug delivery system avoids the route of non-invasive treatment, thus solving the issues of
needle phobia in the patients, thus allowing them to comply with the entire procedure of the drug
administration. The process of the transdermal drug delivery system avoids the system of the pre-systemic
metabolism and thus provides improvisation in the bioavailability of the drug. The research philosophy
that is used in this research study is realism. Realism is used as the research philosophy because realism
solely depends on the real values that are obtained from the part of the research. The research approach
that is used in this research study is the deductive research approach. The significance of the study
revolves around the overall formulation of the drug to be administered, the optimization of the drug
administered to the patients and the evaluation of their effectiveness when they are administered to the
patients who opt for a non-invasive method of drug administration due to problems such as needle
phobia and others. Other forms of research philosophy such as interpretivism, positivism and
pragmatism are not used as the research philosophy in this case because the effects of the drug
administration cannot always be positive, and hence positivism cannot be used as research philosophy.
Nutraceuticals in Pharmaceutical Field
Nutraceuticals are natural chemical compounds used for prevention of disease and health fitness. In
pharmaceutical field, the use of nutraceuticals has gained immense importance in the recent times. The
High-tech treatment of disease with the help of modern methods are included in this type of chemical
compounds. In the below discussion, some famous articles are reviewed to gain a conclusion regarding
the use of nutraceuticals in pharma field. The use of nutraceuticals in food and health are included in this
article review paper along with the new era transition. Medical backgrounds are experiencing immense
transformation due to technical advancements. This article review would help on understanding all of
them with detailed examples and explanation.