About Me |
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I have started working in the research field since my Post graduation Days and still learning and will continue to learn. I have started my career in this university as an Assistant Professor of the Department of Biotechnology and I have worked closely in association with "Gram Tarand Technologies" for almost one year. I am also the domain coordinator for Nutraceuticals. In recent days, I have been working on different research areas including, Nutraceuticals, Phytopharma, and Targeted Drug designing in different pant and animal diseases. I served as the coordinator of the " Research and Application Center for Phytopharma ", a co-founder member of GT Biofuture, and also R&D Coordinator for "Gram Tarang Foods Pvt. Ltd". I am the coordinator of the "Domain Nutraceutical and Animal Cell Culture", presently almost 40 and above students are doing a project under my supervision in the domain "Nutraceutical". I have authored many peer-reviewed journal articles and book Chapters and also edited three books. I am the MD of 1'Gram Tarang Foods Testing lab", which has been funded by GOI, Ministry of Food Processing worth Rs.6.9 core. I am also designated as the "Chief Convener, Culture (CSR) and NSS officer of Group 1" In Parlakhemundi Campus. |
1. In Silico Analysis of different medicinal plant Extract as Bio-pesticides:
Goal: Making of Biopesticides using different medicinal plant extract so that, it has less side effect and high value.
2. Personalized Medicine
Goal: This project is to get some personalized medicine for particular patients.
3. Nutraceuticals
Goal: Nutraceuticals are products, which other than nutrition are also used as medicine. A nutraceutical product may be defined as a substance, which has physiological benefits or provides protection against chronic disease. Nutraceuticals may be used to improve health, delay the aging process, prevent chronic diseases, increase life expectancy, or support the structure or function of the body. Nowadays, nutraceuticals have received considerable interest due to potential nutritional, safety, and therapeutic effects. Recent studies have shown promising results for these compounds in various complications. In the present review, much effort has been devoted to present new concepts about nutraceuticals based on their diseases modifying indications. Emphasis has been made to present herbal nutraceuticals effective on hard curative disorders related to oxidative stress including allergy, Alzheimer's, cardiovascular, cancer, diabetes, eye, immune, inflammatory, and Parkinson's diseases as well as obesity.
4. Phytopharma
Goal: Globally, herbal medicine has been considered an important alternative to modern allopathic medicine. Although herbal medicines are very popular in society, only a few medicinal herbs have been scientifically evaluated for their potential in medical treatment. In most countries, herbal drugs are poorly regulated and are often neither registered nor controlled by the health authorities. The safety of herbal medicines remains a major concern. In the United States, the Food and Drug Administration (FDA) has estimated that over 50,000 adverse events are caused by botanical and other dietary supplements.
5. Affordable and efficacious skincare products based on natural spice extracts obtained from super critical CO2 extraction process (Collaboration with Spice Board and Naturals)
Gentle Micellar Face Cleanser: This will employ micellar technology where the micellar cleansing bubbles will glide over the face attracting make-up and dirt whilst not drying out the skin.
Daily facial Anti-aging & brightening day cream/lotion: This will be formulated to help in skin anti-aging, whilst providing protection against pollution and UV rays. A concoction of turmeric, ginger and cinnamon extracts will form the key active ingredients for this cream/lotion.
Sl. No. | Title | Issuer |
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1 | Best Innovator Award | Novel IPR Academy and AMTZ |
2 | Best paper award in 2nd International Conference on Research Trends in Engineering, Applied Science and Management | (ICRTESM-2018) |
3 | Certificate of Appreciation in recognition for publishing a Patent | Centurion University of Technologies and Management |
4 | Certificate of Appreciation in recognition for publishing a Patent | Centurion University of Technologies and Management |
5 | Certificate of Appreciation in recognition for publishing a Patent | Centurion University of Technologies and Management |
6 | Spice board Project | Spice Board |
The objective of this study is to use the optical fiber, an emerging device due to their biocompatibility, photo-sensitivity, as a biosensor which can detect the mycotoxin produced by the Aspergillus sp. found in food and feed product of animals. First, we have treated the Red Blood Corpuscles (RBCs) of human blood with different concentration of Aflatoxin B1 and Aflatoxin G1 (AflB1 and AflG1respectively) and after certain time slot, we have studied the changes of the RBC and its protein by Circular Dichorism spectroscopy (CD)and, Fluorescent Spectroscopy. From these Spectroscopic data, it has been found that there was a change in the structure of the Haemoglobin (Hb), supported by theReactive Oxygen Species (ROS), which gives the apoptotic dimension of the RBC. These experiments followed by the preparation of the nanoprobe by etching optical nanofibre with Hydrofluoric Acid (HF) upto certain extent. The prepared nanoprobe was then used to detect theAflB1and AflG1treated RBC.The outcome of the experiments it has been found that the optical nanofiber can detect a small variation of pH of the solution.
The naturally occurring resources like coconut oil, ginger extract, and vitamin E possess substantial beneficial effect on human
skin. The phytochemicals of coconut oil and ginger extract have anti-oxidant and anti-microbial activities. In the present work,
a value added virgin coconut oil was developed mixing ginger extract and vitamin E with it. The oil was tested for its efficacy
against bacteria and fungi that are potent causative agents of skin infection in human beings. The oil described in this article, is
rich in anti-oxidants and having anti-aging property. Regular use of this oil may protect the skin from any getting infected by
microbes as well as prevent the skin from premature aging. The extraction of coconut oil, ginger and vitamin E from wheat
germ was done by super critical fluid extraction in pilot scale, using carbon dioxide as solvent. The molecular docking was
done to support the wet lab data of anti-microbial activities of this oil with in-silico analysis.
A review of the literature has shown that there is a high demand for type “O†blood. Type-o positive is the most transfused blood type as it can be given to any patients with RH positive blood type due to the absence of antigens and presence of both antibodies. Meanwhile type o-negative is a universal donor and can be given to patient of any blood type due to the absence of any kind of antigens. The eight different blood types that can be categorized into four groups based on their antigens: A, B, AB, and O with the help of presence on antigens and antibodies which are responsible for the detection of the foreign objects and deal with it. Our aim was to convert the AB blood group to O blood group. Thus it can be safely transfused to anyone without any risk. We have extracted the total DNA from human gut using metagenomics and expressed in E. coli. It eventually led to focus on the mucosal lining of the human gut, which contains sugars that similar in structure to blood antigens. They were then able to “use E. coli to select for DNA containing genes that code for enzymes that can cleave sugar residues.†then multiple the enzymes and found that it was capable of removes the Gal or Gal-NAc residues that determine the antigens of type-A and type-B blood, which essentially makes the blood type-O.2) select specific glycoside hydrolase families of interest and create a phylogenetically distinct sub-families of their genes. From each sub-family select a representative gene and expressed it in E.coli.
Polyethylene terephthalate (PET) is extensively used in plastic products and its accumulation has become a source of pollution. A novel bacterium- Ideonellasakaiensis 201-F6, we have isolated due to its ability to use PET as its major energy and carbon source. Our aim is to use the plastic polymer to break into carbon atoms and which are further being used to prepare degradable Bio plastic. In plastic recycling, chemically-broken down PET is re-synthesized to make new PET. Therefore, it is possible to replace the breakdown process with a biological one to produce degradable plastic. We have used an environment which was rich in CO2 and constant energy resources. The bacteria were being introduce then to the non-degradable plastics and after due course of time we got the bio degradable PET. This amount of PET and time can be varied by the amount of non degradable plastics and bacteria and also on the contents of the plastic products.
Copper has found to be one in every of the main trace components among of all found within the human body and additionally co-factor of quite three hundred class enzymes, plays a very important role in maintaining cellular processes which are crucial as well as stress, desoxyribonucleic acid replication, repairing of DNA, progression of cell cycle and programmed cell death. Thus, it has found to be very evident that Associate in Nursing alteration in Copper levels in willcer cells can cause a harmful result. analysis has shown that low concentration of Copper in cells ends up in the initiation and progression of cancer and high concentration of Copper shows harmful effects. Copper-mediated super molecular activity situation and aerophilous stress through reactive oxygen species (ROS) might also be the probable cause of this cytotoxic result. CuO contains a neutral hydroxyl radical connected to its surface, that plays a very important role in the changes of behaviour of the surface . Our aim is to indicate that the result of Copper oxide and silicon coated copper oxide on totally different microbes and cancer cells. Characterization of Cu nanoparticles have been done by using different analyzing techniques i.e. UV-Vis Spectroscopy, DLS (Dynamic Light Scattering) and SEM (Scanning Electron Microscope). The effect of the Cu nanoparticles on microbes has been measured by the cup disk method where as the effect on cancer cell line (HeLa) (Human Cervical Cancer Cell Line) has been measured by Fluorescence Anisotropy, MTT assay, Reactive Oxygen Species (ROS). The effect on different enzymatic action has also been measured.
Genetically changed or designed foods are made from speedily increasing technologies that have sparked international
debates and considerations regarding health and safety. These considerations target the potential dangers to
human health, the risks of genetic pollution, and also the death of other farming techniques additionally as theft and
economic exploitation by massive non-public fi rms. Transgenic or genetically changed plants possess novel genes
that impart useful characteristics like weed killer resistance. One amongst the smallest amount understood areas
within the environmental risk assessment of genetically changed crops is their impact on soil- and plant-associated
microorganism communities. The popularity that these interactions might amendment microorganism multifariousness
and have an effect on scheme functioning has initiated a restricted range of studies within the space. Moreover,
novel proteins are shown to be free from transgenic plants into the soil scheme, and their presence will infl uence the
multifariousness of the microorganism community by selection stimulating the expansion of organisms that may use
them. Microorganism diversity is altered once related to transgenic plants; but these effects are each variable and
transient. Minor alterations within the diversity of the microorganism community might have an effect on soil health
and scheme functioning, and so, the impact that plant selection might wear the dynamics of the rhizosphere microorganism
populations and successively plant growth and health and scheme property need additional study. Our aim is
to identify the genes by the multiple sequence alignment (MSA) or the proteins related to the gene which are causing
health hazard in human and to reduce the risk by homology modeling and spectroscopic analysis
Fungal infections in animal, plants and fungal contamination of food for humans and livestock result in substantial worldwide economic losses. In the last few years, fungal infection has increased strikingly by a rise in the number
of deaths of acquired immunodefi ciency syndrome (AIDS) cancer patients, transplant patients owing to fungal infections.
The growth rate of fungi is very slow as compared to bacteria and very diffi cult to identify. Approximately 100
peptides have been investigated to date for their antifungal properties, which can be of great importance to overcome
the human diseases. Insects secrete such compounds, which can be peptides, as a part of their immune defense reactions.
Antifungal peptides are excellent models for drug discovery exhibiting unique characteristics such as high
specifi city, broad spectrum, low level of resistance reaching and unique mode of action. The aim of this review is to
provide information on research on these important peptides
Zinc, as one of the major trace elements of the human body and co-factor of more than 300 mammalian enzymes, plays an important role in maintaining crucial cellular processes including oxidative stress, DNA replication, DNA repair, cell
cycle progression and apoptosis. Thus, it is evident that an alteration in zinc levels in cancer cells can cause a deleterious
effect. Research has shown that low zinc concentration in cells leads to the initiation and progression of cancer and high
zinc concentration shows toxic effects. Zinc-mediated protein activity disequilibrium and oxidative stress through reactive
oxygen species (ROS) may be the probable mechanism of this cytotoxic effect. ZnO has a neutral hydroxyl group
attached to its surface, which plays an important role in its surface charge behaviour. Our aim is to show that the effect
of Zinc Oxide and Silica coated Zinc Oxide on different microbes and cancer cells. Characterization of Zn nanoparticles
have been done by using different analyzing techniques i.e. UV-Vis Spectroscopy, DLS (Dynamic Light Scattering) and
SEM (Scanning Electron Microscope). The effect of the Zn nanoparticles on microbes has been measured by the cup disk
method where as the effect on cancer cell line (HeLa) (Human Cervical Cancer Cell Line) has been measured by Fluorescence
Anisotropy, MTT assay, Reactive Oxygen Species (ROS). The effect on different enzymatic action has also been
measured. Regardless of antimicrobial medicinal consideration, dismalness and mortality identifi ed with these microorganism
contaminations remain high, somewhat because of the adaptability of those life forms to create protection from
almost all anti-infection agents. Our aim is to develop new drugs spot and build up the resulting age of prescription or
operators to manage microorganism contaminations.
Plant growth and development are dependent upon complex biochemical reactions where phyto-hormones are key players. Recent scientific developments in the research field of crop physiology have identified a class of novel plant hormones called strigolactones (SLs). Strigol, the first strigolactones was isolated in 1966. After twenty years of this discovery, the structure of strigol was completely elucidated. The significance of strigolactones lies in the fact that they act as rhizosphere signalling molecules, play important role in regulation of plant architecture, promote germination of root parasitic weeds which have fatal effects on plant growth. Strigolactones are play significant roles in plant biotic and abiotic stress responses. They have emerged as important biological targets to study different signalling pathways, stress responses and developmental stages of plant. Presently, two naturally occurring SL families have been reported. One of those is having stereochemical configuration of (+)-strigol and the other is having (−)-orobanchol. The most prominent role of SLs has found to help in seed germination in the Orobanche and Striga, parasitic weeds. They proved to be important bioactive compounds in in-planta and ex-planta signalling pathways and molecular botany. The potential uses of SLs in controlling parasitic weeds seed in agriculture, amplification of the branching in arbuscular mycorrhizal (AM) fungi is discussed in this review along with the biosynthesis, mode of action and roles of synthetic SL mimics in sustainable agriculture are highlighted. The objective of this work is to harness the benefits of SLs for sustainable agriculture in the near future. There are about 285 free full text out which 98 review articles are archived in PubMed database in the last five years, i.e, 2015-20, with the keyword “strigolactoneâ€..
Acne is the world’s most common skin disease. It is an inflammatory disease and mostly teens and adults get affected by the increased sebum production, inflammation and bacterial colonization of hair follicles on
face, chest, back, shoulder and neck by Propionibacterium acne. Acne can persist into adulthood with determinate effects on the self-esteem of the affected which eventually leads to depression. Effective approaches towards the treatment of acne and to know and understand its pathogenesis. Acne affects skin having dense sebaceous follicles in areas including the face, chest, and back. Acne is not life-threatening but severe acne can affect the psychological status and social activities. The present review focuses on epidemiology, etiology, pathogenesis, diagnosis, differential diagnosis, and management of acne with the
pharmaceutical dosage forms of oral and topical administrations. Various medicines for acne treatment include benzoyl peroxide, antibiotics, antiseborrheic medications, sulfur and sodium Sulphacetamide,
anti-androgen medications, salicylic acid, hormonal treatments, alpha hydroxy acid, retinoids, azelaic acid, keratolytic soaps, and nicotinamide. Currently, laser and light devices and minor subcision surgery have been also performed for acne treatment. This review paper lays emphasis on a brief idea on acne treatments, preventions, and acne-causing bacteria Propionibacterium acnes. Youngsters who lose their confidence results in depression and some committed suicide. Youngsters can able to get an idea of how to prevent and treat acne.
As aboriginal sources of medications, medicinal plants are used from the ancient times. Peppermint is one of the highly used potential medicinal plants in the world. This plant is traditionally used for the treatment of common cold, diarrhea, fever due to several infective causes, jaundice, as a health tonic for the liver and cardiovascular health, and as an antioxidant. It is also used to improve sexual dysfunctions and serve as a contraceptive. All parts of this plant are used to extract the active phytochemicals, but the compositions of phytoconstituents widely differ from one part to another and with the place, season, and time of harvest. We are using this property of Peppermint to get some new drugs for Gray mold. The uses of various pesticides, preservatives, etc. turn the foods into poison. Moreover, the side effects of these pesticides and preservatives, etc. are dangerous as because it leads to initiation of
different cancer. In this whole world, the number of patients dying from cancer is increasing in a very threatening way. In-silico analysis has done using software and we further targeted some of the genes responsible for Graymold and pharmacophores from Peppermint and did some in silico analysis. In this we have found that these two pharmacophores are having better Mol Doc score from any others. From this we can deduce that these two pharmacophores can be a solution to Lung Cancer in near future. Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not generally considered part of conventional medicine. As cancer incidence rates and survival time increase, use of CAM will likely increase. However, little is known about the use of CAM in cancer patients, specifically in emerging countries.
As aboriginal sources of medications, medicinal plants are used from the ancient times. Peppermint is one of the highly used potential medicinal plants in the world. This plant is traditionally used for the treatment of common cold, diarrhoea, fever due to several infective cause, jaundice, as a health tonic for the liver and cardiovascular health, and as an antioxidant. It is also used to improve sexual dysfunctions and serve as a contraceptive. All parts of this plant are used to extract the active phytochemicals, but the compositions of phytoconstituents widely differ from one part to another and with place, season, and time of harvest. Salmonella enterica subspecies enterica serovar Typhi (Salmonella typhi) is the cause of typhoid fever and a human host–restricted organism. Our understanding of the global burden of typhoid fever has improved in recent decades, with both an increase in the number and geographic
representation of high-quality typhoid fever incidence studies, and greater sophistication of modeling approaches. The 2017 World Health Organization Strategic Advisory Group of Experts on Immunization
recommendation for the introduction of typhoid conjugate vaccines for infants and children aged >6 months in typhoid-endemic countries is likely to require further improvements in our understanding of typhoid burden at the global and national levels. Furthermore, the recognition of the critical and synergistic role of water and sanitation improvements in concert with vaccine introduction emphasizes the importance of improving our understanding of the sources, patterns, and modes of transmission of
Salmonella typhi in diverse settings.
Trachyspermum ammi (L.) Sprague or commonly Ajwain is a herbaceous herb belonging to the family Apiaceae and vastly grows in Egypt, Iran, Pakistan, Afghanistan, and India as well as European region. Known as Zenyan or Nankhah in medical and pharmaceutical manuscript of medieval Persia, seeds of Ajwain were highly administered by traditional healers and traditionally employed for different ailments. Due to its various chemical constituents, the herb seeds were also evaluated for its numerous pharmacological properties. Accordingly, current work was carried out to review the traditional and modern pharmacological properties of Ajwain regarding current and medieval reports. To this,
respective databases were searched for the terms ‘Trachyspermum ammi’, ‘Carum copticum’, ‘Ajwain’ and ‘Ajowan’ without limitation up to early 2013. Ajwain seeds revealed to possess antiseptic, stimulant,
carminative, diuretic, anesthetic, antimicrobial, antiviral, nematicidal, antiulcer, antihypertensive, antitussive, bronchodilatory, antiplatelet and hepatoprotective as well as antihyperlipidemic effects, many of those were remarked by early Persian physicians. With reference to these pharmacological activities, Ajwain seeds can be a good candidate for to be applied in clinical practice. However, in spite of various experimental and animal studies, lack of comprehensive clinical trials aimed on regarded effects is still remained to reconfirm the traditional knowledge.
Ancient India is one of the pioneers of studies of plants as medicine, i.e. Ayurveda. In our social and economic life we hardly take care of our food we are taking. One such unique herb is Cinnamon which has often been regarded as a brain booster. The whole plant including the flowers can be used for medicinal purposes. It has a bitter and sweet taste and is known to impart a cooling energy. Cinnamon is full of antioxidants that are essential for living a healthy life. Antioxidants help in removing free radicals that can further mutate into cancer cells. We are using this property of Cinnamon to get some new drugs for Crown Gall. The uses of various pesticides, preservatives, etc. turn the foods into poison. Moreover, the side effects of these pesticides and preservatives, etc. are dangerous as because it leads to initiation of different cancer. In this whole world, the number of patients dying from cancer is increasing in a very threatening way. In-silico analysis has done using software and we further targeted some of the genes responsible for Crown Gall and pharmacophores from Cinnamon and did some in silico analysis. In this
we have found that these two pharmacophores are having better Mol Doc score from any others. From this we can deduce that these two pharmacophores can be a solution to Lung Cancer in near future.
Ancient India is one of the pioneers of studies of plants as medicine, i.e. Ayurveda. In our social and economic life we hardly take care of our food we are taking. One such unique herb is Cinnamon which has often been regarded as a brain booster. The whole plant including the flowers can be used for medicinal purposes. It has a bitter and sweet taste and is known to impart a cooling energy. Cinnamon is full of antioxidants that are essential for living a healthy life. Antioxidants help in removing free radicals that can further mutate into cancer cells. We are using this property of Cinnamon to get some new drugs for Gastric Cancer. The uses of various pesticides, preservatives, etc. turn the foods into poison.
Moreover the side effects of these pesticides and preservatives, etc. are dangerous as because it leads to initiation of different cancer. In this whole world, the number of patients dying from cancer is increasing
in a very threatening way. In-silico analysis has done using software and we further targeted some of the genes responsible for Gastric Cancer and pharmacophores from Cinnamon and did some in silico analysis. In this we have found that these two pharmacophores are having better Mol Doc score from any others. From this we can deduce that these two pharmacophores can be a solution to Lung Cancer in near future. Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not generally considered part of conventional medicine. As cancer incidence rates and survival time increase, the use of CAM will likely increase. However, little is known about the use of CAM in cancer patients, specifically in emerging countries.
Zinc, as one of the major trace elements of the human body and co-factor of more than 300 mammalian enzymes, plays an important role in maintaining crucial cellular processes including oxidative stress, DNA replication, DNA repair, cell cycle progression and apoptosis. Thus, it is evident that an alteration in zinc levels in cancer cells can cause a deleterious effect. Research has shown that low zinc concentration in cells leads to the initiation and progression of cancer and high
zinc concentration shows toxic effects. Zinc-mediated protein activity disequilibrium and oxidative stress through reactive oxygen species (ROS) may be the probable mechanism of this cytotoxic effect. ZnO has a neutral hydroxyl group attached to its surface, which plays an important role in its surface charge behaviour. Our aim is to show that the effect
of Zinc Oxide and Silica coated Zinc Oxide on different microbes and cancer cells. Characterization of Zn nanoparticles have been done by using different analyzing techniques i.e. UV-Vis Spectroscopy, DLS (Dynamic Light Scattering) and SEM (Scanning Electron Microscope). The effect of the Zn nanoparticles on microbes has been measured by the cup disk method whereas the effect on cancer cell line (HeLa) (Human Cervical Cancer Cell Line) has been measured by Fluorescence
Anisotropy, MTT assay, Reactive Oxygen Species (ROS). The effect on different enzymatic action has also been measured. Regardless of antimicrobial medicinal consideration, dismalness and mortality identifi ed with these microorganism contaminations remain high, somewhat because of the adaptability of those life forms to create protection from
almost all anti-infection agents. Our aim is to develop new drugs spot and build up the resulting age of prescription or operators to manage microorganism contaminations.
Ancient India is one of the pioneers of studies of plants as medicine, i.e. Ayurveda. In our social and economic life we hardly take care of our food we are taking. Cumin (Cuminum cyminum Linn.) is an important seed spice and one of the earliest known minor spices used by mankind. It is believed to be native of Egypt and Syria, Turkestan and the Eastern Mediterranean region. The typical pleasant aroma of the seeds is due to their volatile oil content, the principal constituent of which is cuminol
(cuminaldehyde). Antioxidants help in removing free radicals that can further mutate into cancer cells. We are using this property of Cumin to get some new drugs for Diarrhoea. The uses of various pesticides, preservatives, etc. turn the foods into poison. Moreover the side effects of these pesticides and preservatives, etc. are dangerous as because it leads to initiation of different cancer. In this whole world, the number of patients dying from cancer is increasing in a very threatening way. In-silico analysis has done using software and we further targeted some of the genes responsible for Diarrhoea and pharmacophores from Cumin and did some in silico analysis. In this we have found that these two
pharmacophores are having better Mol Doc score from any others.
The scientific analysis is carried out all over in India since Vedic times and are present in a group of herbal preparations of the Indian traditional health care system (Ayurveda) proposed for their valuable anticancer and other valuable properties. Numerous forms of cancer accounts for 10% of total death worldwide which requires better therapeutic approaches. Ginger is one of the most commonly used herbal medicines for the treatment of numerous ailments and improvement of body functions.
Compounds of ginger (Zingiber officinale), shown to exhibit antioxidant, anti-inflammatory and anticarcinogenic properties. In current study, we intended to analyze inhibitory properties of ginger towards
target proteins for several cancers by computer aided virtual screening. Docking study revealed that compounds gingerol, shogaol, zingiberol, zingiberene, zingerone, zingerdiol were found to have strong
binding affinity towards selected cancer targets. Hence, these compounds can be further investigated in vitro and in vivo to develop novel chemical scaffold on which further derivatization can be done for further optimization of its anticancer activity.
The naturally occurring resources like coconut oil, ginger extract, and vitamin E possess substantial beneficial effect on human skin. The phytochemicals of coconut oil and ginger extract have anti-oxidant and anti-microbial activities. In the present work, a value added virgin coconut oil was developed mixing ginger extract and vitamin E with it. The oil was tested for its efficacy against bacteria and fungi that are potent causative agents of skin infection in human beings. The oil described in this article, is rich in anti-oxidants and having anti-aging property. Regular use of this oil may protect the skin from any getting infected by microbes as well as prevent the skin from premature aging. The extraction of coconut oil, ginger and vitamin E from wheat germ was done by super critical fluid extraction in pilot scale, using carbon dioxide as solvent. The molecular docking was done to support the wet lab data of anti-microbial activities of this oil with in-silico analysis.
As aboriginal sources of medications, medicinal plants are used from the ancient times. Andrographis paniculata is one of the highly used potential medicinal plants in the world. This plant is traditionally used for the treatment of common cold, diarrhoea, fever due to several infective cause, jaundice, as a health tonic for the liver and cardiovascular health, and as an antioxidant. It is also used to improve sexual dysfunctions and serve as a contraceptive. All parts of this plant are used to extract the active phytochemicals, but the compositions of phytoconstituents widely differ from one part to another and with place, season, and time of harvest. We are using this property of Green Chiretta to get some new drugs for Breast Cancer. The uses of various pesticides, preservatives, etc. turn the foods into poison. Moreover the side effects of these pesticides and preservatives, etc. are dangerous as because it leads to initiation of different cancer. In this whole world, the number of
patients dying from cancer is increasing in a very threatening way. In-silico analysis has done using software and we further targeted some of the genes responsible for Breast Cancer and pharmacophores from Green Chiretta and did some in silico analysis. In this, we have found that these two pharmacophores are having better Mol Doc score from any others. From this we can deduce that these two pharmacophores can be a solution to Lung Cancer in near future. Complementary and alternative medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not generally considered part of conventional medicine. As cancer incidence rates and survival time increase, use of CAM will likely increase. However, little is known about the use of CAM in cancer patients, specifically in emerging countries.
Concept of the Proposal:
Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesise hundreds of chemical compounds for functions including defence against insects, fungi, diseases, and herbivorous mammals. Numerous phytochemicals with potential or established biological activity have been identified. However, since a single plant contains widely diverse phytochemicals, the effects of using a whole plant as medicine are uncertain. Further, the phytochemical content and pharmacological actions, if any, of many plants having medicinal potential remain unassessed by rigorous scientific research to define efficacy and safety.
Objective:
Biopesticides are certain types of pesticides that are derived from natural materials like plants (Botanical origin ), bacteria, fungi and virus (Microbial origin) and certain minerals. When used as a component of Integrated Pest Management (IPM) programs these biopesticides can
greatly decrease the use of conventional pesticides, while crop yields remain high. The BioPesticides control pests / diseases either selectively or with broad-spectrum approach. Biopesticides are usually inherently less toxic than conventional pesticides. Biopesticides are generally target specific and affect only the target pest and closely related organisms vis-à-vis broad spectrum, conventional pesticides that may also affect organisms such as birds, insects and mammals. We want to define this problem with a bio-solution using BIOVIA and some other fieldwork.
Concept of the proposal:
Ancient India is one of the pioneers of studies of plants as medicine, i.e. Ayurveda. In our social and economic life, we hardly take care of the food we are taking. The uses of various pesticides, preservatives, etc. turn the foods into poison. Moreover the side effects of these pesticides and preservatives etc. are dangerous because it leads to the initiation of different cancer. In this whole world, the number of patients dying from cancer is increasing in a very threatening way. We found Medicinal plant is packed with antioxidants that help in detoxing and cleansing from within. The medicinal plant is a source of powerful antioxidants. Phenolic compounds like catechin, alkanols, apigenin, and linalool are found in Coriandrum sativum. These kinds of antioxidants help to scavenge free radicals, which can be very detrimental to the body if not cleared properly. The Medicinal plant is also thought to have potent anticancer abilities against some cancer cell lines. Due in large part to its antioxidant capabilities, the medicinal plant is considered a possible tool to help treat cancer. Extract from the root of the plant has been shown to inhibit DNA damage, prevent cancer cell migration, and promote cancer cell death in laboratory studies. Several components of Medicinal plant help fight cancer. This occurs either by causing cell death directly or boosting your immune system so that your body is better able to fight off cancer on its own. Medicinal plant tea is sometimes used as an adjuvant therapy during chemotherapy and radiation. It helps in removal of toxins from the body by relieving fluid retention. It has to be a potential drug for cancer in the wet lab using different methods like, Fluorescence Spectroscopy, Reactive Oxygen Species (ROS), MTT assay, Circular Dichroism (CD). After getting a good result we further targeted some of the genes responsible for Cancer IL6 (6MG1), VDR (5XZF), MTOR (5YK5) and pharmacophores Decene (6DJC), 2- Bornyl acetate (5ZF4) from Medicinal plant and did some in silico analysis. In this, we have found that these two pharmacophores are having better Mol Doc score from any others. From this, we can deduce that these two pharmacophores can be a solution to Cancer in near future.
Objective:
We have first studied the effect of Medicinal plant extract on Cancer cell line and the observed some significant result in MTT assay, followed by ROS analysis and Fluorescence Anisotropy, from which we have decided to target some genes responsible for Cancer IL6 (6MG1), VDR (5XZF), MTOR (5YK5) and pharmacophores Decene (6DJC), 2- Bornyl acetate (5ZF4) from Medicinal plant. After identification of the genes and pharmacophores, we did the docking and got some positive value. From this analysis report, this can be concluded that some pharmacophores of Medicinal plant have an effect on the Cancer. Some of the animal studies followed by the isolation of the targeted pharmacophore and the effect on the gene (in-vitro and in-vivo analysis) are on process. Based on this the new drug design is also in the long term future work.
Preparation of Herbal Extract:
1) Selection of the plant 2) Collecting the Plant, 3) Preparing the plant extract: It involves steps such as cutting , washing and chopping of the plant and then extraction 4) Keeping it for a period of at least 3-4 weeks before using it 5) Filtration 6) Storage under refrigerated conditions
Because of the higher amount of sugar, the flowers are utilized as a sweetener in preparation of numerous traditional dishes like halwa, kheer, methi puri, and barfi in mahua production belt of India. Tribal people use mahua flowers for curing skin diseases, headache, pitta, and bronchitis.
Different plant extracts in various forms have been used in traditional skincare routines for centuries. Especially in Indian subcontinent ancient scriptures mention a wide range of natural sources for skin care as well as treatment of skin related ailments. In fact, plant sources were the primary source of all beauty products before synthetic formulations having similar effects were produced industrially. Though synthetic substances often result in quick and better effects, there can be adverse effects in long-term use. Also, there are adverse environmental impacts of those substances, as they can leach into water bodies and harm aquatic life. For example, various sunscreen lotions are widely used to protect skin from harmful UV radiation which contains chemical sunscreen agents. Prolonged use of these substances can cause health hazards1 as well as the adverse impacts on aquatic life. are Increasing consumer awareness for sustainable products has encouraged many researchers to find greener alternatives to synthetic cosmetics.
The objective of the proposed project
1. To develop an easy, economic, environment-friendly process for extraction of essential oils from spices using SCF extraction technique.
2. To develop novel formulations of skin care products using the spice extracts
3. To replace the harmful chemical compounds generally used in skin care products, with natural ingredients.
Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity. Due to an increasing demand for chemical diversity in screening programs, seeking therapeutic drugs from natural products, interest particularly in edible plants has grown throughout the world. Botanicals and herbal preparations for medicinal usage contain various types of bioactive compounds. The focus of this paper is on the analytical methodologies, which include the extraction, isolation and characterization of active ingredients in botanicals and herbal preparations.
Gentle Micellar Face Cleanser: This will employ micellar technology where the micellar cleansing bubbles will glide over the face attracting make-up and dirt whilst not drying out the skin.
Ashwagandha extract will form the key active ingredient with its antimicrobial and antibacterial properties along with its with anolides providing strong anti-inflammatory effects.
Daily facial Anti-aging & brightening day cream/lotion: This will be formulated to help in skin anti-aging, whilst providing protection against pollution and UV rays. A concoction of turmeric, ginger and cinnamon extracts will form the key active ingredients for this cream/lotion.
? Turmeric: On skin, in vivo research has shown that turmeric and its derivatives interrupt signaling in surface cells that trigger signs of irritation, this helps calm skin and may even play a role in reducing the look of acne-related redness by modulating pathways to restore a healthier, more even appearance. Research has also conclusively shown that turmeric is a potent antioxidant which can help offset signs of aging, environmental damage and, to some extent, thwart the skin-damaging effects from UVB light. Apart from being an antioxidant, research has shown the curcumin portion of turmeric boosts skin’s hyaluronic acid helping with the moisture balance of skin.
? Ginger: Gingerol, an active component of Ginger (Zingiber officinale), shows antipyretic and anti-inflammatory activities. It inhibits melanin synthesis in murine B16F10 melanoma cells, by reducing MITF and inhibiting the tyrosinase activity, thereby
helping in skin brightening.
? Cinnamon: Cinnamaldehyde is the major active component in Cinnamon extract that induces type I collagen biosynthesis. The underlying molecular mechanism is believed to trigger the activation of Insulin-like growth factor-I (IGF-I) signaling via the direct IGF-
I receptor activating pathway. These findings could be helpful in improving the signs and symptoms of the ageing skin.